S
Sepide Derakhshan
Publications - 4
Citations - 455
Sepide Derakhshan is an academic researcher. The author has contributed to research in topics: Urine cytology & Kidney tumour. The author has an hindex of 2, co-authored 4 publications receiving 220 citations.
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Journal ArticleDOI
Tubuloids derived from human adult kidney and urine for personalized disease modeling
Frans Schutgens,Frans Schutgens,Maarten B. Rookmaaker,Thanasis Margaritis,Anne C. Rios,Carola Ammerlaan,Carola Ammerlaan,Jitske Jansen,Linda Gijzen,Marianne K. Vormann,Annelotte M. Vonk,Marco C. Viveen,Fjodor A. Yousef Yengej,Fjodor A. Yousef Yengej,Sepide Derakhshan,Karin M. de Winter-de Groot,Benedetta Artegiani,Ruben van Boxtel,Edwin Cuppen,Antoni P. A. Hendrickx,Marry M. van den Heuvel-Eibrink,Ellen Heitzer,Henriëtte L. Lanz,Jeffrey M. Beekman,Jean-Luc Murk,Rosalinde Masereeuw,Frank C. P. Holstege,Jarno Drost,Marianne C. Verhaar,Hans Clevers +29 more
TL;DR: Conditions for the long-term growth of primary kidney tubular epithelial organoids, or ‘tubuloids’, are described and tubuloids grown from human kidney tissue and urine aid the study of BK virus infection, Wilms tumors and cystic fibrosis.
Journal ArticleDOI
An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity.
Camilla Calandrini,Frans Schutgens,Rurika Oka,Thanasis Margaritis,Tito Candelli,Luka Mathijsen,Carola Ammerlaan,Ravian L. van Ineveld,Sepide Derakhshan,Sanne de Haan,Emmy Dolman,Philip Lijnzaad,Lars Custers,Harry Begthel,Hindrik H. D. Kerstens,Lindy L. Visser,Maarten B. Rookmaaker,Marianne C. Verhaar,Godelieve A.M. Tytgat,Patrick Kemmeren,Ronald R. de Krijger,Reem Al-Saadi,Kathy Pritchard-Jones,Marcel Kool,Anne C. Rios,Marry M. van den Heuvel-Eibrink,Jan J. Molenaar,Ruben van Boxtel,Frank C. P. Holstege,Hans Clevers,Jarno Drost +30 more
TL;DR: The first paediatric cancer organoid biobank of tumour and matching normal kidney organoids from over 50 children with different subtypes of kidney cancer is described, providing a representative collection of well-characterised models for basic cancer research, drug-screening and personalised medicine.
Journal ArticleDOI
Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors.
Camilla Calandrini,Sander R. van Hooff,Irene Paassen,Dilara Ayyildiz,Sepide Derakhshan,M. Emmy M. Dolman,Karin P. S. Langenberg,Marieke van de Ven,Cecilia de Heus,Nalan Liv,Marcel Kool,Ronald R. de Krijger,Godelieve A.M. Tytgat,Marry M. van den Heuvel-Eibrink,Jan J. Molenaar,Jarno Drost +15 more
TL;DR: In this paper, the authors performed drug screening on patient-derived normal and tumor organoids to identify MRT-specific therapeutic vulnerabilities and identified neddylation inhibitor MLN4924 as a potential therapeutic agent.
Journal ArticleDOI
Loss of FLCN-FNIP1/2 induces a non-canonical interferon response in human renal tubular epithelial cells
Iris E. Glykofridis,Jaco C. Knol,Jesper A. Balk,Denise Westland,Thang V. Pham,Sander R. Piersma,Sinéad M. Lougheed,Sepide Derakhshan,Puck Veen,Martin A. Rooimans,Saskia E. van Mil,Franziska Böttger,Pino J Poddighe,Irma van de Beek,Jarno Drost,Fried J. T. Zwartkruis,Renee X. de Menezes,Hanne Meijers-Heijboer,Arjan C. Houweling,Connie R. Jimenez,Rob M. F. Wolthuis +20 more
TL;DR: In this paper, the authors show that Folliculin loss promotes STAT2 recruitment to chromatin and slows cellular proliferation and identify STAT1/2 signaling as a novel target of FLCN in renal cells and BHD tumors.