L
Linda Gijzen
Researcher at Radboud University Nijmegen
Publications - 8
Citations - 503
Linda Gijzen is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Kidney & In vivo. The author has an hindex of 5, co-authored 8 publications receiving 251 citations.
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Journal ArticleDOI
Tubuloids derived from human adult kidney and urine for personalized disease modeling
Frans Schutgens,Frans Schutgens,Maarten B. Rookmaaker,Thanasis Margaritis,Anne C. Rios,Carola Ammerlaan,Carola Ammerlaan,Jitske Jansen,Linda Gijzen,Marianne K. Vormann,Annelotte M. Vonk,Marco C. Viveen,Fjodor A. Yousef Yengej,Fjodor A. Yousef Yengej,Sepide Derakhshan,Karin M. de Winter-de Groot,Benedetta Artegiani,Ruben van Boxtel,Edwin Cuppen,Antoni P. A. Hendrickx,Marry M. van den Heuvel-Eibrink,Ellen Heitzer,Henriëtte L. Lanz,Jeffrey M. Beekman,Jean-Luc Murk,Rosalinde Masereeuw,Frank C. P. Holstege,Jarno Drost,Marianne C. Verhaar,Hans Clevers +29 more
TL;DR: Conditions for the long-term growth of primary kidney tubular epithelial organoids, or ‘tubuloids’, are described and tubuloids grown from human kidney tissue and urine aid the study of BK virus infection, Wilms tumors and cystic fibrosis.
Journal ArticleDOI
Nephrotoxicity and Kidney Transport Assessment on 3D Perfused Proximal Tubules
Marianne K. Vormann,Linda Gijzen,Simon Hutter,Lisette Boot,Arnaud Nicolas,Angelique van den Heuvel,Jelle Vriend,Chee Ping Ng,Tom T. G. Nieskens,Vincent van Duinen,Bjorn de Wagenaar,Rosalinde Masereeuw,Laura Suter-Dick,Sebastiaan Johannes Trietsch,Martijn J. Wilmer,Jos Joore,Paul Vulto,Henriëtte L. Lanz +17 more
TL;DR: An advanced in vitro model consisting of fully polarized renal proximal tubular epithelial cells cultured in a microfluidic system is described that can be used for drug screening studies.
Journal ArticleDOI
Fluorescence-Based Transport Assays Revisited in a Human Renal Proximal Tubule Cell Line
Pedro Caetano-Pinto,Manoe J. Janssen,Linda Gijzen,Laurens F. M. Verscheijden,Martijn J. Wilmer,Rosalinde Masereeuw +5 more
TL;DR: Fluorescence-probe-based assays are fast and reproducible in determining apical transport mechanisms, in vitro and demonstrate that typical substrates and inhibitors are not specific for the designated transporters, reflecting the complex interactions that can take place in vivo.
Journal ArticleDOI
Implementation of a Human Renal Proximal Tubule on a Chip for Nephrotoxicity and Drug Interaction Studies.
Marianne K. Vormann,Jelle Vriend,Henriëtte L. Lanz,Linda Gijzen,Angelique van den Heuvel,Simon Hutter,Jos Joore,Sebastiaan Johannes Trietsch,Christiaan Stuut,Tom T. G. Nieskens,Janny G. P. Peters,Daniela Ramp,Michaela Caj,Frans G. M. Russel,Björn Jacobsen,Adrian Roth,Shuyan Lu,Joseph W. Polli,Anita A. Naidoo,Paul Vulto,Rosalinde Masereeuw,Martijn J. Wilmer,Laura Suter-Dick +22 more
TL;DR: Nephroscreen as mentioned in this paper is a high throughput, 3D microfluidic platform for the detection of drug-induced kidney injury (DIKI) in pharmaceutical development and drug-transporter interactions.
Journal ArticleDOI
An Intestine-on-a-Chip Model of Plug-and-Play Modularity to Study Inflammatory Processes.
Linda Gijzen,Diego Marescotti,Elisa Raineri,Arnaud Nicolas,Henriëtte Leonore Lanz,Diego Guerrera,Remko van Vught,Jos Joore,Paul Vulto,Manuel C. Peitsch,Julia Hoeng,Giuseppe Lo Sasso,Dorota Kurek +12 more
TL;DR: The model provides biological modularity for key aspects of intestinal inflammation, making use of well-established cell lines, and allows robust assays that can be tailored in complexity to serve all preclinical stages in the drug discovery and development process.