J
Jean Lud Cadet
Researcher at National Institute on Drug Abuse
Publications - 386
Citations - 24202
Jean Lud Cadet is an academic researcher from National Institute on Drug Abuse. The author has contributed to research in topics: Meth- & Methamphetamine. The author has an hindex of 81, co-authored 385 publications receiving 22555 citations. Previous affiliations of Jean Lud Cadet include United States Department of Health and Human Services & Columbia University.
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Dose-related neurocognitive effects of marijuana use
TL;DR: Very heavy use of marijuana is associated with persistent decrements in neurocognitive performance even after 28 days of abstinence, and it is unclear if these decrements will resolve with continued abstinence or become progressively worse with continued heavy marijuana use.
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Methamphetamine toxicity and messengers of death
Irina N. Krasnova,Jean Lud Cadet +1 more
TL;DR: The accumulated evidence indicates that multiple events converge to mediate METH-induced terminal degeneration and neuronal apoptosis, and suggest that pharmacological strategies geared towards the prevention and treatment of the deleterious effects of this drug will need to attack the various pathways that form the substrates of METH toxicity.
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Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making task
Karen I. Bolla,Dana A. Eldreth,Edythe D. London,Kent A. Kiehl,Kent A. Kiehl,M. Mouratidis,Carlo Contoreggi,John A. Matochik,V. Kurian,Jean Lud Cadet,Alane S. Kimes,Frank R. Funderburk,Monique Ernst +12 more
TL;DR: It is suggested that cocaine abusers show persistent functional abnormalities in prefrontal neural networks involved in decision-making and these effects are related to cocaine abuse.
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Free radicals and the pathobiology of brain dopamine systems.
Jean Lud Cadet,Christie Brannock +1 more
TL;DR: The thesis that the neurodegenerative effects of two drugs, namely methamphetamine and methylenedioxymethamphetamine are due to ROS overproduction in monoaminergic systems in the brain is elaborate and the role of oxygen-based species in 6-hydroxydopamine-induced nigrostriatal dopaminergic degeneration and in Parkinson's disease is discussed.
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Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity
Serge Przedborski,Vladimir Kostic,Vernice Jackson-Lewis,Ali Naini,S Simonetti,Stanley Fahn,E Carlson,CJ Epstein,Jean Lud Cadet +8 more
TL;DR: Results suggest that increased SOD activity is, most likely, the protective factor that confers resistance to transgenic mice against MPTP-induced neurotoxicity, and provides further evidence that some of the deleterious effects of MPTP may be mediated by O2- radicals.