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Irina N. Krasnova
Researcher at United States Department of Health and Human Services
Publications - 49
Citations - 3458
Irina N. Krasnova is an academic researcher from United States Department of Health and Human Services. The author has contributed to research in topics: Methamphetamine & Meth-. The author has an hindex of 31, co-authored 48 publications receiving 3127 citations. Previous affiliations of Irina N. Krasnova include National Institute on Drug Abuse & National Institutes of Health.
Papers
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Journal ArticleDOI
Methamphetamine toxicity and messengers of death
Irina N. Krasnova,Jean Lud Cadet +1 more
TL;DR: The accumulated evidence indicates that multiple events converge to mediate METH-induced terminal degeneration and neuronal apoptosis, and suggest that pharmacological strategies geared towards the prevention and treatment of the deleterious effects of this drug will need to attack the various pathways that form the substrates of METH toxicity.
Journal ArticleDOI
Neurotoxicity of substituted amphetamines: molecular and cellular mechanisms.
TL;DR: The toxic effects of AMPH, METH and MDMA are summarized and some of the factors that are thought to underlie this toxicity are presented, which include oxidative stress, hyperthermia, excitotoxicity and various apoptotic pathways.
Journal ArticleDOI
Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology.
Bagrat Abazyan,Jun Nomura,Geetha Kannan,Koko Ishizuka,Kellie L.K. Tamashiro,Frederick Nucifora,Vladimir M. Pogorelov,Bruce Ladenheim,Chunxia Yang,Irina N. Krasnova,Jean Lud Cadet,Carlos A. Pardo,Susumu Mori,Atsushi Kamiya,Michael W. Vogel,Akira Sawa,Christopher A. Ross,Mikhail V. Pletnikov +17 more
TL;DR: Prenatal immune activation interacted with mh DISC1 to produce the neurobehavioral phenotypes that were not seen in untreated mhDISC1 mice and that resemble aspects of major mental illnesses.
Book ChapterDOI
Molecular Bases of Methamphetamine-Induced Neurodegeneration
Jean Lud Cadet,Irina N. Krasnova +1 more
TL;DR: In this article, the authors review cellular and molecular mechanisms that might be responsible for METH neurotoxicity, including oxidative stress, activation of transcription factors, DNA damage, excitotoxicity, blood-brain barrier breakdown, microglial activation, and various apoptotic pathways.
Journal ArticleDOI
Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders.
Yavuz Ayhan,Bagrat Abazyan,Jun Nomura,R Kim,Bruce Ladenheim,Irina N. Krasnova,Akira Sawa,Russell L. Margolis,Jean Lud Cadet,Susumu Mori,Michael W. Vogel,Christopher A. Ross,Mikhail V. Pletnikov +12 more
TL;DR: The data show that mutant hDISC1 exerts differential effects on neurobehavioral phenotypes, depending on the stage of development at which the protein is expressed.