Jean-Marie Darbon

TL;DR: The data show that CIP2A is associated with clinical aggressivity in human breast cancer and promotes the malignant growth of breast cancer cells.

TL;DR: A molecular signature specifying a subgroup of patients who do not gain benefits from tamoxifen treatment is identified and these patients may therefore be eligible for alternative endocrine therapies and/or chemotherapy.

TL;DR: The results reinforce the hypothesis of a negative modulatory role of protein kinase C in MCF-7 cell proliferation but suggest that the two activators TPA and DiC8 could induce distinct molecular events with regard to the enzyme recruitment and activity as well as to its further processing.

TL;DR: It is reported that the LY 294002‐induced G1 arrest is closely correlated to inhibition of CDK4 and CDK2 activities leading to the impairment of pRb phosphorylation which normally occurs during G1 progression.

TL;DR: TNF-α may drastically reduce the capacity of granulosa cells to differentiate upon FSH stimulation and to respond to LH during the physiological ovarian follicular maturation, suggesting that anti-gonadotropic action of TNF-β may be also relevant to the alteration of ovarian function during physiopathological processes like inflammatory or infection diseases.