F
Franck Molina
Researcher at Centre national de la recherche scientifique
Publications - 93
Citations - 4619
Franck Molina is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Epitope & Context (language use). The author has an hindex of 30, co-authored 91 publications receiving 4087 citations. Previous affiliations of Franck Molina include University of Cambridge & Epigenomics AG.
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Journal ArticleDOI
Clinical validation of the detection of KRAS and BRAF mutations from circulating tumor DNA
Alain R. Thierry,Florent Mouliere,Safia El Messaoudi,Caroline Mollevi,Evelyne Lopez-Crapez,Fanny Rolet,Brigitte Gillet,Céline Gongora,Pierre Déchelotte,Bruno Robert,Maguy Del Rio,Pierre-Jean Lamy,Frédéric Bibeau,Michelle Nouaille,Virginie Loriot,Anne Sophie Jarrousse,Franck Molina,Muriel Mathonnet,Denis Pezet,Marc Ychou +19 more
TL;DR: This study shows that liquid biopsy through cfDNA analysis could advantageously replace tumor-section analysis and expand the scope of personalized medicine for patients with cancer.
Journal ArticleDOI
High Fragmentation Characterizes Tumour-Derived Circulating DNA
Florent Mouliere,Bruno Robert,Erika Arnau Peyrotte,Maguy Del Rio,Marc Ychou,Franck Molina,Céline Gongora,Alain R. Thierry +7 more
TL;DR: Q-PCR analysis of plasma samples from xenografted mice and cancer patients showed that tumour-derived ct DNA exhibits a specific amount profile based on ctDNA size and significant higher cTDNA fragmentation.
Journal ArticleDOI
Recommendations for Biomarker Identification and Qualification in Clinical Proteomics
Harald Mischak,Guenter Allmaier,Rolf Apweiler,Teresa K. Attwood,Marc Baumann,Ariela Benigni,Samuel E. Bennett,Rainer Bischoff,Erik Bongcam-Rudloff,Giovambattista Capasso,Joshua J. Coon,Patrick C. D'Haese,Anna F. Dominiczak,Mohammed Dakna,Hassan Dihazi,Jochen H. H. Ehrich,Patricia Fernández-Llama,Danilo Fliser,Jørgen Frøkiær,Jérôme Garin,Mark Girolami,William S. Hancock,Marion Haubitz,Denis F. Hochstrasser,Rury R. Holman,John P. A. Ioannidis,Joachim Jankowski,Bruce A. Julian,Jon B. Klein,Walter Kolch,Theo M. Luider,Ziad A. Massy,William B. Mattes,Franck Molina,Bernard Monsarrat,Jan Novak,Karlheinz Peter,Peter Rossing,Marta Sanchez-Carbayo,Joost P. Schanstra,O. John Semmes,Goce Spasovski,Dan Theodorescu,Visith Thongboonkerd,Raymond Vanholder,Timothy D. Veenstra,Eva M. Weissinger,Tadashi Yamamoto,Antonia Vlahou +48 more
TL;DR: It is asserted that successful studies generally use suitable statistical approaches for biomarker definition and confirm results in independent test sets and a brief set of practical and feasible recommendations are described for investigators to properly identify and qualify proteomic biomarkers, which could also be used as reporting requirements.
Journal ArticleDOI
Origin and quantification of circulating DNA in mice with human colorectal cancer xenografts
Alain R. Thierry,Florent Mouliere,Céline Gongora,Jeremy Ollier,Bruno Robert,Marc Ychou,Maguy Del Rio,Franck Molina +7 more
TL;DR: The results suggest that ctDNA features vary during CRC tumor development and an experimental system to systematically examine these aspects might be a useful tool to follow such variations.
Journal ArticleDOI
Detection of pathological biomarkers in human clinical samples via amplifying genetic switches and logic gates
TL;DR: It is reported that bacterial biosensors with genetically encoded digital amplifying genetic switches can detect clinically relevant biomarkers in human urine and serum and can be used to detect pathological glycosuria in urine from diabetic patients.