Jean-Paul Leroux

TL;DR: It is shown that among the macromolecules present in human adult liver microsomes, one protein called cytochrome P-450-8 is specifically recognized by most sera of patients containing anti-LKM2 antibodies but not by control serum, suggesting a possible mechanism for the appearance of anti-organelle antibodies in a drug-induced hepatitis.

TL;DR: It is concluded that modified nucleotides have a predominant role in canonical folding of human mitochondrial tRNALys and a major contribution of m1A9 in this process is argued.

TL;DR: A CPT II deficiency associating hypoketotic hypoglycemia, high plasma creatine kinase level, heart beat disorders, and sudden death in a 3-mo-old boy is described.

TL;DR: The monooxygenase activities, the sensitivity to in vitro alpha-naphthoflavone and metyrapone, the results of steroid metabolism, and slab gel electrophoresis are strong indications for multiplicity of human liver cytochrome P-450.

TL;DR: When aerobically incubated with liver microsomes and NADPH, chloroform produces a stable adduct with cysteine as a nucleophilic trapping agent that was identified by thin layer chromatography, gas-liquid chromatography and combined gas chromatography-mass spectrometry as the reaction product of Cysteine with phosgene.