Jean Pierre Cravedi

TL;DR: In rats orally exposed for one week to E171 at human relevant levels, titanium was detected in the immune cells of Peyer’s patches (PP) as observed with the TiO2-NP model NM-105, and these data should be considered for risk assessments of the susceptibility to Th17-driven autoimmune diseases and to colorectal cancer in humans exposed toTiO2 from dietary sources.

TL;DR: This study demonstrates the estrogenic activity of BPA, BPF and BPS in different cell- and tissue-contexts and at different stages of development, confirming the relevance of combining cellular and whole-organism bioassays in a unique model species for the hazard assessment of candidate EDCs.

TL;DR: It is demonstrated that some human cell lines extensively metabolize BPA and BPF and establish the genotoxic potential of bisphenol F.

TL;DR: It is shown that a TH derivative, triiodothyroacetic acid (TRIAC), induces metamorphosis in the cephalochordate amphioxus, and conservation of a regulatory network supports the homology of metamorphotic in the chordate lineage.

TL;DR: It is shown that chronic exposure to a mixture of a dose of a phytoestrogen equivalent to that in the human diet and a low dose—albeit not environmental—of a common anti-androgenic food contaminant may seriously affect the male reproductive tract and fertility.