P
Paavo K. Paakko
Researcher at National Institutes of Health
Publications - 3
Citations - 1297
Paavo K. Paakko is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Alpha (ethology) & Respiratory epithelium. The author has an hindex of 3, co-authored 3 publications receiving 1274 citations.
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Journal ArticleDOI
Adenovirus-mediated transfer of a recombinant alpha 1-antitrypsin gene to the lung epithelium in vivo
Melissa A. Rosenfeld,Wolfgang Siegfried,Kunihiko Yoshimura,Koichi Yoneyama,Masashi Fukayama,L Stier,Paavo K. Paakko,Pascale Gilardi,L D Stratford-Perricaudet,Michel Perricaudet,Sophie Jallat,Andrea Pavirani,Jean-Pierre Lecocq,Ronald G. Crystal +13 more
TL;DR: The respiratory epithelium is a potential site for somatic gene therapy for the common hereditary disorders alpha 1-antitrypsin (alpha 1AT) deficiency and cystic fibrosis by infecting epithelial cells of the cotton rat respiratory tract in vitro and in vivo.
Journal ArticleDOI
Expression of the cystic fibrosis transmembrane conductance regulator gene in the respiratory tract of normal individuals and individuals with cystic fibrosis
Bruce C. Trapnell,Chin-Shyan Chu,Paavo K. Paakko,Tyrone C. Banks,Kunihiko Yoshimura,Victor J. Ferrans,Milica S. Chernick,Ronald G. Crystal +7 more
TL;DR: Estimation of CFTR gene expression quantified by limited polymerase chain reaction amplification showed that in normal individuals, CFTR mRNA transcripts are expressed in nasal, tracheal, and bronchial epithelial cells at approximately 1-2 copies per cell, more than 100-fold greater than in pharyngeal epithelium.
Journal ArticleDOI
Human neutrophils express the alpha 1-antitrypsin gene and produce alpha 1-antitrypsin.
R M du Bois,J F Bernaudin,Paavo K. Paakko,R Hubbard,H Takahashi,Victor J. Ferrans,Ronald G. Crystal +6 more
TL;DR: The concept that human neutrophils may be able to modulate the extracellular activity of NE by synthesizing and secreting alpha 1AT is evaluated, which indicates that the neutrophil is capable, to some extent, of modulating NE activity in the local milieu without the help of antiproteases produced by other cells.