J
Jeanine D. Mattson
Researcher at Schering-Plough
Publications - 41
Citations - 12438
Jeanine D. Mattson is an academic researcher from Schering-Plough. The author has contributed to research in topics: Cytotoxic T cell & T cell. The author has an hindex of 21, co-authored 41 publications receiving 11827 citations. Previous affiliations of Jeanine D. Mattson include Merck & Co..
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Journal ArticleDOI
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Claire L. Langrish,Yi Yi Chen,Wendy M. Blumenschein,Jeanine D. Mattson,Beth Basham,Jonathan D. Sedgwick,Terrill K. McClanahan,Robert A. Kastelein,Daniel J. Cua +8 more
TL;DR: Using passive transfer studies, it is confirmed that these IL-23–dependent CD4+ T cells are highly pathogenic and essential for the establishment of organ-specific inflammation associated with central nervous system autoimmunity.
Journal ArticleDOI
Development, cytokine profile and function of human interleukin 17-producing helper T cells
Nicholas J. Wilson,Katia Boniface,Jason R. Chan,Brent S. McKenzie,Wendy M. Blumenschein,Jeanine D. Mattson,Beth Basham,Kathleen M. Smith,Taiying Chen,Franck Morel,Jean-Claude Lecron,Robert A. Kastelein,Daniel J. Cua,Terrill K. McClanahan,Edward P. Bowman,Rene de Waal Malefyt +15 more
TL;DR: It is demonstrated that IL-23 and IL-1β induced the development of human and mouse TH-17 cells expressing IL-17A,IL-17F, IL-22, Il-26, interferon-γ, the chemokine CCL20 and transcription factor RORγt, and that human TH- 17 cells may regulate innate immunity in epithelial cells.
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IL-23 is essential for T cell–mediated colitis and promotes inflammation via IL-17 and IL-6
David C. Yen,Jeanne Cheung,Heleen Scheerens,Frederique M. Poulet,Terrill K. McClanahan,Brent S. McKenzie,Melanie A. Kleinschek,Alexander Owyang,Jeanine D. Mattson,Wendy M. Blumenschein,Erin Murphy,Manjiri Sathe,Daniel J. Cua,Robert A. Kastelein,Donna Rennick +14 more
TL;DR: This study shows that in these models, IL-23 is essential for manifestation of chronic intestinal inflammation, whereas IL-12 is not, and a critical target of IL- 23 is a unique subset of tissue-homing memory T cells, which are specifically activated by IL-21 to produce the proinflammatory mediators IL-17 and IL-6.
Journal ArticleDOI
IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4+ T Cells
Stefan Pflanz,Jackie C. Timans,Jeanne Cheung,Rency Rosales,Holger Kanzler,Jonathan M. Gilbert,Linda Hibbert,Tatyana Churakova,Marilyn Travis,Elena Vaisberg,Wendy M. Blumenschein,Jeanine D. Mattson,Janet Wagner,Wayne To,Sandra Zurawski,Terrill K. McClanahan,Daniel M. Gorman,J. Fernando Bazan,Rene de Waal Malefyt,Donna Rennick,Robert A. Kastelein +20 more
TL;DR: A new heterodimeric cytokine termed IL-27 is described that consists of EBI3, an IL-12p40-related protein, and p28, a newly discovered IL- 12p35-related polypeptide and drives rapid clonal expansion of naive but not memory CD4(+) T cells.
Journal ArticleDOI
IL-23 promotes tumour incidence and growth
John L. Langowski,Xueqing Zhang,Lingling Wu,Jeanine D. Mattson,Taiying Chen,Kathy Smith,Beth Basham,Terrill K. McClanahan,Robert A. Kastelein,Martin Oft +9 more
TL;DR: It is shown that IL-23 is an important molecular link between tumour-promoting pro-inflammatory processes and the failure of the adaptive immune surveillance to infiltrate tumours.