J
Jeff Holst
Researcher at University of New South Wales
Publications - 93
Citations - 5900
Jeff Holst is an academic researcher from University of New South Wales. The author has contributed to research in topics: Glutamine & Prostate cancer. The author has an hindex of 35, co-authored 87 publications receiving 4634 citations. Previous affiliations of Jeff Holst include St. Jude Children's Research Hospital & Centenary Institute.
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Journal ArticleDOI
Distinct Immune Cell Populations Define Response to Anti-PD-1 Monotherapy and Anti-PD-1/Anti-CTLA-4 Combined Therapy
Tuba N. Gide,Camelia Quek,Alexander M. Menzies,Annie Tasker,Ping Shang,Jeff Holst,Jason Madore,Su Yin Lim,Su Yin Lim,Rebecca Velickovic,Matthew Wongchenko,Yibing Yan,Serigne Lo,Matteo S. Carlino,Alexander Guminski,Robyn P. M. Saw,Robyn P. M. Saw,Angel Pang,Helen M. McGuire,Umaimainthan Palendira,John F. Thompson,John F. Thompson,Helen Rizos,Helen Rizos,Ines Pires da Silva,Marcel Batten,Richard A. Scolyer,Richard A. Scolyer,Georgina V. Long,James S. Wilmott +29 more
TL;DR: An EOMES+CD69+CD45RO+ effector memory T cell phenotype that was significantly more abundant in responders to combined immunotherapy compared with non-responders was associated with longer progression-free survival in patients treated with single agent and greater tumor shrinkage in both treatments.
Journal ArticleDOI
Orchestrated Intron Retention Regulates Normal Granulocyte Differentiation
Justin J.-L. Wong,Justin J.-L. Wong,William Ritchie,William Ritchie,Olivia A. Ebner,Matthias Selbach,Jason W. H. Wong,Yizhou Huang,Dadi Gao,Dadi Gao,Natalia Pinello,Natalia Pinello,María Jesús González González,María Jesús González González,Kinsha Baidya,Kinsha Baidya,Annora Thoeng,Annora Thoeng,Teh-Liane Khoo,Teh-Liane Khoo,Charles G. Bailey,Charles G. Bailey,Jeff Holst,Jeff Holst,John E.J. Rasko,John E.J. Rasko,John E.J. Rasko +26 more
TL;DR: Bioinformatic analyses of transcriptomic and proteomic data of normal white blood cell differentiation reveal IR as a physiological mechanism of gene expression control and establish that IR coupled with NMD is a conserved mechanism in normal granulopoiesis.
Journal ArticleDOI
ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer
M van Geldermalsen,M van Geldermalsen,Qian Wang,Qian Wang,Rajini Nagarajah,Rajini Nagarajah,Amy D. Marshall,Amy D. Marshall,Annora Thoeng,Annora Thoeng,Dadi Gao,Dadi Gao,William Ritchie,William Ritchie,Yue Feng,Yue Feng,Charles G. Bailey,Charles G. Bailey,Niantao Deng,Niantao Deng,Kate Harvey,Kate Harvey,Jane Beith,C.I. Selinger,Sandra A O'Toole,Sandra A O'Toole,Sandra A O'Toole,John E.J. Rasko,John E.J. Rasko,John E.J. Rasko,Jeff Holst,Jeff Holst +31 more
TL;DR: Preclinical evidence for the feasibility of novel therapies exploiting ASCT2 transporter activity in breast cancer is provided, particularly in the high-risk basal-like subgroup of TN breast cancer where there is not only high expression of AsCT2, but also a marked reliance on its activity for sustained cellular proliferation.
Journal ArticleDOI
Substrate elasticity provides mechanical signals for the expansion of hemopoietic stem and progenitor cells.
Jeff Holst,Sarah L. Watson,Megan S. Lord,Steven S. Eamegdool,Daniel V. Bax,Lisa Nivison-Smith,Alexey Kondyurin,Liang Ma,Andres F. Oberhauser,Anthony S. Weiss,John E.J. Rasko,John E.J. Rasko,John E.J. Rasko +12 more
TL;DR: The data suggest that substrate elasticity and tensegrity are important mechanisms influencing hemopoietic stem and progenitor cell subsets and could be exploited to facilitate cell culture.
Journal ArticleDOI
Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration
Seher Balaban,Robert F. Shearer,Lisa S. Lee,Michelle van Geldermalsen,Mark Schreuder,Mark Schreuder,Harrison C. Shtein,Rose Cairns,Kristen C. Thomas,Daniel J. Fazakerley,Thomas Grewal,Jeff Holst,Darren N. Saunders,Darren N. Saunders,Andrew J. Hoy +14 more
TL;DR: It is shown that co-culture of breast cancer cells with adipocytes revealed cancer cell-stimulated depletion of adipocyte triacylglycerol, highlighting a novel and potentially important role for adipocyte lipolysis in the provision of metabolic substrates to Breast cancer cells, thereby supporting cancer progression.