Ping Shang

TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

TL;DR: Analysis of whole-genome sequences from cutaneous, acral and mucosal subtypes of melanoma reveals diverse carcinogenic processes across its subtypes, some unrelated to sun exposure, and extends potential involvement of the non-coding genome in its pathogenesis.

TL;DR: An EOMES+CD69+CD45RO+ effector memory T cell phenotype that was significantly more abundant in responders to combined immunotherapy compared with non-responders was associated with longer progression-free survival in patients treated with single agent and greater tumor shrinkage in both treatments.

TL;DR: A genomic landscape analysis of samples collected from three continents reveals a potential role for CDK4/6 or MEK inhibition in the treatment of the disease.

TL;DR: NK cells may play an important role in mediating response to anti-PD-1 therapy, including in a subset of tumors downregulating MHC class I expression, which prevents T cell recognition of the tumor.