M
Matthias Selbach
Researcher at Max Delbrück Center for Molecular Medicine
Publications - 149
Citations - 21146
Matthias Selbach is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: Gene & Proteome. The author has an hindex of 49, co-authored 135 publications receiving 18130 citations. Previous affiliations of Matthias Selbach include Charité & University of Southern Denmark.
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Global quantification of mammalian gene expression control
Björn Schwanhäusser,Dorothea Busse,Na Li,Gunnar Dittmar,Johannes Schuchhardt,Jana Wolf,Wei Chen,Matthias Selbach +7 more
TL;DR: Using a quantitative model, the first genome-scale prediction of synthesis rates of mRNAs and proteins is obtained and it is found that the cellular abundance of proteins is predominantly controlled at the level of translation.
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Widespread changes in protein synthesis induced by microRNAs
Matthias Selbach,Björn Schwanhäusser,Nadine Thierfelder,Zhuo Fang,Raya Khanin,Nikolaus Rajewsky +5 more
TL;DR: It is shown that a single miRNA can repress the production of hundreds of proteins, but that this repression is typically relatively mild, and the data suggest that a mi RNA can, by direct or indirect effects, tune protein synthesis from thousands of genes.
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The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts
Alexander G. Baltz,Mathias Munschauer,Björn Schwanhäusser,Alexandra Vasile,Yasuhiro Murakawa,Markus Schueler,Noah Youngs,Duncan Penfold-Brown,Kevin Drew,Miha Milek,Emanuel Wyler,Richard Bonneau,Matthias Selbach,Christoph Dieterich,Markus Landthaler +14 more
TL;DR: Protein occupancy profiling provides a transcriptome-wide catalog of potential cis-regulatory regions on mammalian mRNAs and showed that large stretches in 3' UTRs can be contacted by the mRNA-bound proteome, with numerous putative binding sites in regions harboring disease-associated nucleotide polymorphisms.
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A practical guide to the MaxQuant computational platform for SILAC-based quantitative proteomics
Jürgen Cox,Ivan Matic,Maximiliane Hilger,Nagarjuna Nagaraj,Matthias Selbach,Jesper V. Olsen,Matthias Mann +6 more
TL;DR: This protocol explains step by step how to use MaxQuant on stable isotope labeling by amino acids in cell culture (SILAC) data obtained with double or triple labeling.
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Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR.
Svetlana Lebedeva,Marvin Jens,Kathrin Theil,Björn Schwanhäusser,Matthias Selbach,Markus Landthaler,Nikolaus Rajewsky +6 more
TL;DR: Thousands of direct and functional HuR targets are identified, a human miRNA controlled by HuR is found, and a role for HuR in splicing is proposed, validating functionality.