J
Jeffrey S. Rush
Researcher at University of Kentucky
Publications - 67
Citations - 2351
Jeffrey S. Rush is an academic researcher from University of Kentucky. The author has contributed to research in topics: Endoplasmic reticulum & Dolichol. The author has an hindex of 27, co-authored 66 publications receiving 2198 citations.
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Erythroglycan, a high molecular weight glycopeptide with the repeating structure [galactosyl-(1 leads to 4)-2-deoxy-2-acetamido-glucosyl(1 leads to 3)] comprising more than one-third of the protein-bound carbohydrate of human erythrocyte stroma.
TL;DR: Erythroglycan may have the same type of keratan-like core structure as the long chain blood group glycolipids from human erythrocytes and could be a protein-bound carrier of the ABO determinants.
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Deficiency of UDP‐GlcNAc:Dolichol Phosphate N‐Acetylglucosamine‐1 Phosphate Transferase (DPAGT1) Causes a Novel Congenital Disorder of Glycosylation Type Ij
Xiaohua Wu,Jeffrey S. Rush,Denise Karaoglu,Donna M. Krasnewich,Mark S. Lubinsky,Charles J. Waechter,Reid Gilmore,Hudson H. Freeze +7 more
TL;DR: A novel CDG type, CDG‐Ij, is identified, resulting from deficiency in UDP‐GlcNAc: dolichol phosphate N‐acetyl‐glucosamine‐1 phosphate transferase (GPT) activity encoded by DPAGT1, which is concluded to be responsible for the CDG symptoms in this patient.
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The LPP1 and DPP1 gene products account for most of the isoprenoid phosphate phosphatase activities in Saccharomyces cerevisiae.
Alexander J. Faulkner,Xiaoming Chen,Xiaoming Chen,Jeffrey S. Rush,Bruce F. Horazdovsky,Charles J. Waechter,George M. Carman,Paul C. Sternweis +7 more
TL;DR: Results indicate that LPP1 and DPP1 account for most of the hydrolytic activities toward isoprenoid pyrophosphates, dolichyl-P-P, farnesyl-F-P -P, and geranylgeranyl-p-P but also suggest that yeast contain other enzymes capable of dephosphorylating these essential isopranoid intermediates.
Journal ArticleDOI
Nogo‐B receptor is necessary for cellular dolichol biosynthesis and protein N‐glycosylation
Kenneth D. Harrison,Eon Joo Park,Ningguo Gao,Andrew Kuo,Jeffrey S. Rush,Charles J. Waechter,Mark A. Lehrman,William C. Sessa +7 more
TL;DR: Identification of Nogo‐B receptor (NgBR) as an essential component of the cis‐IPTase machinery yields insights into the regulation of dolichol biosynthesis.
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Evidence That the wzxE Gene of Escherichia coli K-12 Encodes a Protein Involved in the Transbilayer Movement of a Trisaccharide-Lipid Intermediate in the Assembly of Enterobacterial Common Antigen
Paul D. Rick,Kathleen Barr,Krishnan Sankaran,Junko Kajimura,Jeffrey S. Rush,Charles J. Waechter +5 more
TL;DR: Results support the conclusion that thewzxE gene encodes a membrane protein involved in the transbilayer movement of lipid III in E. coli.