J
Jelita Roseman
Researcher at University of Chicago
Publications - 6
Citations - 318
Jelita Roseman is an academic researcher from University of Chicago. The author has contributed to research in topics: Amyloid precursor protein & Endosome. The author has an hindex of 5, co-authored 6 publications receiving 290 citations.
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Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase
Virginie Buggia-Prevot,Celia G. Fernandez,Sean M. Riordan,Kulandaivelu S. Vetrivel,Jelita Roseman,Jack Waters,Vytautas P. Bindokas,Robert Vassar,Gopal Thinakaran +8 more
TL;DR: The results reveal novel information on dynamic BACE1 transport in neurons, and demonstrate that Rab11-GTPase function is critical for axonal sorting of Bace1.
Journal ArticleDOI
A Function for EHD Family Proteins in Unidirectional Retrograde Dendritic Transport of BACE1 and Alzheimer’s Disease Aβ Production
Virginie Buggia-Prevot,Celia G. Fernandez,Vinod Udayar,Kulandaivelu S. Vetrivel,Aureliane Elie,Jelita Roseman,Verena A. Sasse,Margaret Lefkow,Xavier Meckler,Sohinee Bhattacharyya,Manju George,Satyabrata Kar,Vytautas P. Bindokas,Angèle T. Parent,Lawrence Rajendran,Hamid Band,Robert Vassar,Gopal Thinakaran +17 more
TL;DR: Unidirectional endocytic transport of a dendritic cargo is demonstrated and a role for EHD proteins in neuronal BACE1 transcytosis and Aβ production is revealed, processes that are highly relevant for Alzheimer's disease.
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Reduced Alzheimer's Disease β-Amyloid Deposition in Transgenic Mice Expressing S-Palmitoylation-Deficient APH1aL and Nicastrin
Xavier Meckler,Jelita Roseman,Pritam Das,Haipeng Cheng,Susan Pei,Marcia Keat,Breanne Kassarjian,Todd E. Golde,Angèle T. Parent,Gopal Thinakaran +9 more
TL;DR: It is found that lack of S-palmitoylation did not impair the ability of APH1aL and nicastrin to form enzymatically active protein complexes with endogenous presenilin 1 and PEN2 or affect the localization of γ-secretase subunits in dendrites and axons of cortical neurons.
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Transgenic neuronal overexpression reveals that stringently regulated p23 expression is critical for coordinated movement in mice
Ping Gong,Jelita Roseman,Celia G. Fernandez,Kulandaivelu S. Vetrivel,Vytautas P. Bindokas,Lois A. Zitzow,Satyabrata Kar,Angèle T. Parent,Gopal Thinakaran +8 more
TL;DR: It is found that even a 50% increase in p23 levels in the central nervous system of mice causes post-natal growth retardation, severe neurological problems characterized by tremors, seizure, ataxia, and uncoordinated movements, and premature death.
Journal ArticleDOI
Regulation of dynamic BACE1 trafficking in neurons.
Virginie Buggia-Prevot,Celia G. Fernandez,Sean M. Riordan,Kulandaivelu S. Vetrivel,Vinod Udayar,Aureliane Elie,Margaret Lefkow,Jelita Roseman,Xavier Meckler,Sohinee Bhattacharyya,Manju George,Jack Waters,Vytautas P. Bindokas,Angèle T. Parent,Lawrence Rajendran,Hamid Band,Robert Vassar,Gopal Thinakaran +17 more
TL;DR: The results suggest that BACE1 trafficking in neuronal recycling endosomes is likely relevant for presynaptic Aβ production and contributes to Alzheimer’s disease pathogenesis.