J
Jen-Tsan Chi
Researcher at Duke University
Publications - 131
Citations - 10324
Jen-Tsan Chi is an academic researcher from Duke University. The author has contributed to research in topics: Gene expression profiling & Cancer. The author has an hindex of 43, co-authored 121 publications receiving 8651 citations. Previous affiliations of Jen-Tsan Chi include Durham University & Stanford University.
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Journal ArticleDOI
Diversity, topographic differentiation, and positional memory in human fibroblasts
Howard Y. Chang,Jen-Tsan Chi,Sandrine Dudoit,Chanda Bondre,Matt van de Rijn,David Botstein,Patrick O. Brown +6 more
TL;DR: Cultured fetal and adult human fibroblasts maintained key features of HOX gene expression patterns established during embryogenesis, suggesting that HOX genes may direct topographic differentiation and underlie the detailed positional memory in fibro Blasts.
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Endothelial cell diversity revealed by global expression profiling
Jen-Tsan Chi,Howard Y. Chang,Guttorm Haraldsen,Frode L. Jahnsen,Olga G. Troyanskaya,Dustin S. Chang,Zhen Wang,Stanley G. Rockson,Matt van de Rijn,David Botstein,Patrick O. Brown +10 more
TL;DR: Tissue-specific expression patterns in different tissue microvascular ECs suggest they are distinct differentiated cell types that play roles in the local physiology of their respective organs and tissues.
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Gene Expression Programs in Response to Hypoxia: Cell Type Specificity and Prognostic Significance in Human Cancers
Jen-Tsan Chi,Jen-Tsan Chi,Zhen Wang,Dimitry S.A. Nuyten,Edwin H. Rodriguez,Marci E. Schaner,Ali Salim,Yun Wang,Gunnar B. Kristensen,Åslaug Helland,Anne Lise Børresen-Dale,Amato J. Giaccia,Michael T. Longaker,Trevor Hastie,George P. Yang,Marc J. van de Vijver,Patrick O. Brown +16 more
TL;DR: A gene-expression signature of the hypoxia response, derived from studies of cultured mammary and renal tubular epithelial cells, showed coordinated variation in several human cancers, and was a strong predictor of clinical outcomes in breast and ovarian cancers.
Journal ArticleDOI
A viral microRNA functions as an orthologue of cellular miR-155
Eva Gottwein,Neelanjan Mukherjee,Christoph Sachse,Corina Frenzel,William H. Majoros,Jen-Tsan Chi,Ravi Braich,Muthiah Manoharan,Jürgen Soutschek,Uwe Ohler,Bryan R. Cullen +10 more
TL;DR: It is reported that the miR-K12-11 miRNA encoded by Kaposi’s-sarcoma-associated herpes virus shows significant homology to cellular mi-155, including the entire miRNA ‘seed’ region.
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Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality
Denise A. Chan,Patrick D. Sutphin,Phuong Nguyen,Sandra Turcotte,Edwin W. Lai,Alice Banh,Gloria E. Reynolds,Jen-Tsan Chi,Jason Wu,David E. Solow-Cordero,Muriel Bonnet,Jack U. Flanagan,Donna M. Bouley,Edward E. Graves,William A. Denny,Michael P. Hay,Amato J. Giaccia +16 more
TL;DR: A screen identifies a drug that specifically kills glycolysis-dependent cancer cells by inhibiting glucose uptake and identifies a class of compounds, the 3-series, exemplified by STF-31, which selectively kills RCCs by specifically targeting glucose uptake through GLUT1 and exploiting the unique dependence of these cells onGLUT1 for survival.