J
Jen-Tsan Chi
Researcher at Duke University
Publications - 131
Citations - 10324
Jen-Tsan Chi is an academic researcher from Duke University. The author has contributed to research in topics: Gene expression profiling & Cancer. The author has an hindex of 43, co-authored 121 publications receiving 8651 citations. Previous affiliations of Jen-Tsan Chi include Durham University & Stanford University.
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Journal ArticleDOI
Genomewide view of gene silencing by small interfering RNAs
TL;DR: It is shown that siRNA-induced gene silencing of transient or stably expressed mRNA is highly gene-specific and does not produce secondary effects detectable by genomewide expression profiling.
Journal ArticleDOI
Systemic and cell type-specific gene expression patterns in scleroderma skin.
Michael L. Whitfield,Deborah Finlay,John I. Murray,Olga G. Troyanskaya,Jen-Tsan Chi,Alexander Pergamenschikov,Timothy H. McCalmont,Patrick O. Brown,David Botstein,David Botstein,M. Kari Connolly +10 more
TL;DR: Analysis of lymphocyte populations in scleroderma skin biopsies by immunohistochemistry suggest the B lymphocyte signature observed on arrays is from CD20+ B cells, and suggests genes that could be used as potential markers for the disease.
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microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease.
TL;DR: The findings suggest that erythroid microRNAs can serve as genetic modifiers of HbS-related anemia and can provide novel insights into the clinical heterogeneity and pathobiology of sickle cell disease.
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Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells
Heather A. Himburg,Garrett G. Muramoto,Pamela Daher,Sarah K. Meadows,J. Lauren Russell,Phuong L. Doan,Jen-Tsan Chi,Alice B. Salter,William Lento,Tannishtha Reya,Nelson J. Chao,John P. Chute +11 more
TL;DR: It is shown that pleiotrophin, a neurite outgrowth factor with no known function in hematopoiesis, efficiently promotes HSC expansion in vitro and HSC regeneration in vivo, and is identified as a new regulator of both H SC expansion and regeneration.
Journal ArticleDOI
Translocation of Sickle Cell Erythrocyte MicroRNAs into Plasmodium falciparum Inhibits Parasite Translation and Contributes to Malaria Resistance
Gregory LaMonte,Nisha Philip,Joseph M. Reardon,Joshua R. Lacsina,William H. Majoros,Lesley Chapman,Courtney D. Thornburg,Marilyn J. Telen,Uwe Ohler,Christopher V. Nicchitta,Timothy A.J. Haystead,Jen-Tsan Chi +11 more
TL;DR: Sickle cell erythrocytes exhibit cell-intrinsic resistance to malaria in part through an atypical miRNA activity, which may represent a unique host defense strategy against complex eukaryotic pathogens.