Jen-Tsan Chi

TL;DR: Cultured fetal and adult human fibroblasts maintained key features of HOX gene expression patterns established during embryogenesis, suggesting that HOX genes may direct topographic differentiation and underlie the detailed positional memory in fibro Blasts.

TL;DR: Tissue-specific expression patterns in different tissue microvascular ECs suggest they are distinct differentiated cell types that play roles in the local physiology of their respective organs and tissues.

TL;DR: A gene-expression signature of the hypoxia response, derived from studies of cultured mammary and renal tubular epithelial cells, showed coordinated variation in several human cancers, and was a strong predictor of clinical outcomes in breast and ovarian cancers.

TL;DR: It is reported that the miR-K12-11 miRNA encoded by Kaposi’s-sarcoma-associated herpes virus shows significant homology to cellular mi-155, including the entire miRNA ‘seed’ region.

TL;DR: A screen identifies a drug that specifically kills glycolysis-dependent cancer cells by inhibiting glucose uptake and identifies a class of compounds, the 3-series, exemplified by STF-31, which selectively kills RCCs by specifically targeting glucose uptake through GLUT1 and exploiting the unique dependence of these cells onGLUT1 for survival.