J
Jennifer E. Snyder-Cappione
Researcher at Boston University
Publications - 40
Citations - 1789
Jennifer E. Snyder-Cappione is an academic researcher from Boston University. The author has contributed to research in topics: Immune system & Natural killer T cell. The author has an hindex of 17, co-authored 35 publications receiving 1263 citations. Previous affiliations of Jennifer E. Snyder-Cappione include University of California, San Francisco.
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Journal ArticleDOI
B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile
Jason DeFuria,Anna C. Belkina,Madhumita Jagannathan-Bogdan,Jennifer E. Snyder-Cappione,Jordan Carr,Yanina R. Nersesova,Douglas Markham,Katherine J. Strissel,Amanda A. Watkins,Min Zhu,Jessica Allen,Jacqueline Bouchard,Gianluca Toraldo,Ravi Jasuja,Martin S. Obin,Marie E. McDonnell,Caroline M. Apovian,Gerald V. Denis,Barbara S. Nikolajczyk +18 more
TL;DR: The conclusion that B cells are critical regulators of inflammation in T2D due to their direct ability to promote proinflammatory T-cell function and secrete a proinflammatory cytokine profile is supported.
Journal ArticleDOI
Automated optimized parameters for T-distributed stochastic neighbor embedding improve visualization and analysis of large datasets.
Anna C. Belkina,Christopher O. Ciccolella,Rina Anno,Richard Halpert,Josef Spidlen,Jennifer E. Snyder-Cappione +5 more
TL;DR: In this article, an automated toolkit for t-SNE parameter selection was developed that utilizes Kullback-Leibler divergence evaluation in real time to tailor the early exaggeration and overall number of gradient descent iterations in a dataset-specific manner.
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Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation
Leena P. Bharath,Madhur Agrawal,Grace McCambridge,Dequina A. Nicholas,Hatice Hasturk,Jing Liu,Kai Jiang,Rui Liu,Zhenheng Guo,Jude T. Deeney,Caroline M. Apovian,Jennifer E. Snyder-Cappione,Gregory S. Hawk,Rebecca Fleeman,Riley M.F. Pihl,Katherine L. Thompson,Anna C. Belkina,Licong Cui,Licong Cui,Elizabeth A. Proctor,Philip A. Kern,Barbara S. Nikolajczyk +21 more
TL;DR: It is concluded that metformin improves autophagy and mitochondrial function largely in parallel to ameliorate a newly defined inflammaging profile that echoes inflammation in diabetes.
Journal ArticleDOI
Functionally distinct subsets of human NK cells and monocyte/DC-like cells identified by coexpression of CD56, CD7, and CD4
Jeffrey M. Milush,Brian Long,Jennifer E. Snyder-Cappione,Amedeo Cappione,Vanessa A. York,Lishomwa C. Ndhlovu,Lewis L. Lanier,Jakob Michaëlsson,Douglas F. Nixon +8 more
TL;DR: Novel subsets of peripheral blood CD3/14/19(neg) NK cells and monocyte/dendritic cell (DC)-like cells were identified on the basis of CD7 and CD4 expression to improve the ability to study the intricacies of NK-cell subset phenotypes and functions in vivo.
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Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection
Lishomwa C. Ndhlovu,Joan M. Chapman,Aashish R. Jha,Jennifer E. Snyder-Cappione,Moraima Pagan,Fabio E. Leal,Brigid S. Boland,Philip J. Norris,Michael G. Rosenberg,Douglas F. Nixon +9 more
TL;DR: HIV-1-infected children with plasma viremia below 50 copies/ml had IL-17 production, whereas those with detectable viresmia had minimal secretion, implying viral-mediated destruction or impairment of Th17 cells and arguing for complete suppression of vire Mia for reconstitution of Th 17 cells.