J
Jennifer L Harcourt
Researcher at Centers for Disease Control and Prevention
Publications - 60
Citations - 13331
Jennifer L Harcourt is an academic researcher from Centers for Disease Control and Prevention. The author has contributed to research in topics: Coronavirus & Medicine. The author has an hindex of 19, co-authored 51 publications receiving 9800 citations. Previous affiliations of Jennifer L Harcourt include University of Washington & National Center for Immunization and Respiratory Diseases.
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Journal ArticleDOI
Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1.
Neeltje van Doremalen,Trenton Bushmaker,Dylan H. Morris,Myndi G. Holbrook,Amandine Gamble,Brandi N. Williamson,Azaibi Tamin,Jennifer L Harcourt,Natalie J. Thornburg,Susan I. Gerber,James O. Lloyd-Smith,Emmie de Wit,Vincent J. Munster +12 more
TL;DR: Aerosol and Surface Stability of SARS-CoV-2 In this research letter, investigators report on the stability of Sars-CoVs and the viability of the two virus under experimental conditions.
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Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility.
Melissa M. Arons,Kelly M Hatfield,Sujan C Reddy,Anne Kimball,Allison E James,Jesica R. Jacobs,Joanne Taylor,Kevin B. Spicer,Ana C Bardossy,Lisa P. Oakley,Sukarma Tanwar,Jonathan W Dyal,Josh Harney,Zeshan Chisty,Jeneita M. Bell,Mark Methner,Prabasaj Paul,Christina M. Carlson,Heather P. McLaughlin,Natalie J. Thornburg,Suxiang Tong,Azaibi Tamin,Ying Tao,Anna Uehara,Jennifer L Harcourt,Shauna Clark,Claire Brostrom-Smith,Libby C. Page,Meagan Kay,James S. Lewis,Patty Montgomery,Nimalie D. Stone,Thomas A. Clark,Margaret A. Honein,Jeffrey S. Duchin,John A. Jernigan +35 more
TL;DR: Rapid and widespread transmission of SARS-CoV-2 was demonstrated in this skilled nursing facility and infection-control strategies focused solely on symptomatic residents were not sufficient to prevent transmission.
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An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice.
Timothy P. Sheahan,Amy C. Sims,Shuntai Zhou,Rachel L. Graham,Andrea J. Pruijssers,Maria L. Agostini,Sarah R. Leist,Alexandra Schäfer,Kenneth H. Dinnon,Laura J. Stevens,James D. Chappell,Xiaotao Lu,Tia M. Hughes,Amelia S. George,Collin S. Hill,Stephanie A. Montgomery,Ariane J. Brown,Gregory R. Bluemling,Michael G. Natchus,Manohar Saindane,Alexander A. Kolykhalov,George R. Painter,Jennifer L Harcourt,Azaibi Tamin,Natalie J. Thornburg,Ronald Swanstrom,Mark R. Denison,Ralph S. Baric +27 more
TL;DR: It is shown that the ribonucleoside analog β-d-N4-hydroxycytidine (NHC; EIDD-1931) has broad-spectrum antiviral activity against SARS- coV-2, MERS-CoV, SARS, and related zoonotic group 2b or 2c bat-CoVs, as well as increased potency against a CoV bearing resistance mutations to the nucleosid analog inhibitor remdesivir
Journal ArticleDOI
Severe Acute Respiratory Syndrome Coronavirus 2 from Patient with Coronavirus Disease, United States.
Jennifer L Harcourt,Jennifer L Harcourt,Azaibi Tamin,Xiaoyan Lu,Shifaq Kamili,Senthil Kumar K. Sakthivel,Janna Murray,Krista Queen,Ying Tao,Clinton R. Paden,Jing Zhang,Yan Li,Anna Uehara,Haibin Wang,Cynthia S. Goldsmith,Hannah A. Bullock,Lijuan Wang,Brett Whitaker,Brian Lynch,Rashi Gautam,Craig Schindewolf,Kumari G. Lokugamage,Dionna Scharton,Jessica A. Plante,Divya Mirchandani,Steven G. Widen,Krishna Narayanan,Shinji Makino,Thomas G. Ksiazek,Kenneth S. Plante,Scott C. Weaver,Stephen Lindstrom,Suxiang Tong,Suxiang Tong,Vineet D. Menachery,Vineet D. Menachery,Natalie J. Thornburg,Natalie J. Thornburg,Natalie J. Thornburg +38 more
TL;DR: It is found that the virus replicates to high titer in Vero-CCL81 cells and Vero E6 cells in the absence of trypsin, and it is hoped that open access to this reagent will expedite development of medical countermeasures.
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US CDC Real-Time Reverse Transcription PCR Panel for Detection of Severe Acute Respiratory Syndrome Coronavirus 2.
Xiaoyan Lu,Lijuan Wang,Senthilkumar K. Sakthivel,Brett Whitaker,Janna Murray,Shifaq Kamili,Brian Lynch,Lakshmi Malapati,Stephen A. Burke,Jennifer L Harcourt,Azaibi Tamin,Natalie J. Thornburg,Julie Villanueva,Stephen Lindstrom +13 more
TL;DR: A diagnostic panel consisting of 3 real-time reverse transcription PCR assays targeting the nucleocapsid gene and evaluated use of these assays for detecting SARS-CoV-2 infection, which obtained no false-positive amplifications with other human coronaviruses or common respiratory pathogens.