J
Jennifer M. Frost
Researcher at University of California, Berkeley
Publications - 37
Citations - 2128
Jennifer M. Frost is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: DNA methylation & Genomic imprinting. The author has an hindex of 15, co-authored 31 publications receiving 1820 citations. Previous affiliations of Jennifer M. Frost include Queen Mary University of London & King's College London.
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Journal ArticleDOI
Declining brain activity in cognitively normal apolipoprotein E epsilon 4 heterozygotes: A foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's disease.
Eric M. Reiman,Richard J. Caselli,Kewei Chen,Gene E. Alexander,Daniel Bandy,Jennifer M. Frost +5 more
TL;DR: This study provides a paradigm for testing the potential of treatments to prevent the disorder without having to study thousands of research subjects or wait many years to determine whether or when treated individuals develop symptoms.
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Regulation of transposable elements by DNA modifications
TL;DR: Current evidence implicating DNA modifications and DNA-modifying enzymes in TE regulation across different species is discussed, and DNA methylation dynamics play a central role in the multilayered epigenetic mechanisms regulating TEs.
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The importance of imprinting in the human placenta.
TL;DR: The development of the human placenta is discussed and the significance of genes that lack conservation of imprinting between mice and humans, genes whose imprinted expression is often placental-specific are discussed.
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The genetic aetiology of Silver–Russell syndrome
Sayeda Abu-Amero,David Monk,Jennifer M. Frost,Michael A. Preece,Philip Stanier,Gudrun E. Moore +5 more
TL;DR: Chromosome 11 has moved to the forefront as the key chromosome in the aetiology, with reports of methylation defects in the H19 imprinted domain associated with the phenotype in 35–65% of SRS patients.
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Valproic Acid Confers Functional Pluripotency to Human Amniotic Fluid Stem Cells in a Transgene-free Approach
Dafni Moschidou,Sayandip Mukherjee,Michael P. Blundell,Katharina Drews,Gemma N. Jones,Hassan Abdulrazzak,Beata Nowakowska,Anju Phoolchund,Kenneth Lay,T Selvee Ramasamy,Mara Cananzi,Daniel Nettersheim,Mark H.F. Sullivan,Jennifer M. Frost,Gudrun E. Moore,Joris Vermeesch,Nicholas M. Fisk,Adrian J. Thrasher,Anthony Atala,James Adjaye,James Adjaye,Hubert Schorle,Paolo De Coppi,Pascale V. Guillot +23 more
TL;DR: It is shown that c-KIT+ human first-trimester amniotic fluid stem cells (AFSCs) can be fully reprogrammed to pluripotency without ectopic factors and are utilized for cell banking of patient-specific pluripotent cells for potential applications in allogeneic cellular replacement therapies, pharmaceutical screening, and disease modeling.