K
Kenneth Lay
Researcher at Agency for Science, Technology and Research
Publications - 16
Citations - 1233
Kenneth Lay is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Stem cell & Induced pluripotent stem cell. The author has an hindex of 12, co-authored 16 publications receiving 908 citations. Previous affiliations of Kenneth Lay include Howard Hughes Medical Institute & Genome Institute of Singapore.
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In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators
TL;DR: The studies unveil TCF3/4–TLE histone deacetylases as a repressive rheostat, whose action can be relieved by Wnt–β-catenin signalling, and who is dispensable for HFSC viability and proliferation if TCF 3/4 levels are sufficiently reduced.
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Valproic Acid Confers Functional Pluripotency to Human Amniotic Fluid Stem Cells in a Transgene-free Approach
Dafni Moschidou,Sayandip Mukherjee,Michael P. Blundell,Katharina Drews,Gemma N. Jones,Hassan Abdulrazzak,Beata Nowakowska,Anju Phoolchund,Kenneth Lay,T Selvee Ramasamy,Mara Cananzi,Daniel Nettersheim,Mark H.F. Sullivan,Jennifer M. Frost,Gudrun E. Moore,Joris Vermeesch,Nicholas M. Fisk,Adrian J. Thrasher,Anthony Atala,James Adjaye,James Adjaye,Hubert Schorle,Paolo De Coppi,Pascale V. Guillot +23 more
TL;DR: It is shown that c-KIT+ human first-trimester amniotic fluid stem cells (AFSCs) can be fully reprogrammed to pluripotency without ectopic factors and are utilized for cell banking of patient-specific pluripotent cells for potential applications in allogeneic cellular replacement therapies, pharmaceutical screening, and disease modeling.
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Modeling of lamin A/C mutation premature cardiac aging using patient-specific induced pluripotent stem cells
Chung-Wah Siu,Yee-Ki Lee,Jenny C. Y. Ho,Wing-Hon Lai,Yau-Chi Chan,Kwong-Man Ng,Lai-Yung Wong,Ka-Wing Au,Yee-Man Lau,Jinqiu Zhang,Kenneth Lay,Alan Colman,Hung-Fat Tse +12 more
TL;DR: It is demonstrated that haploinsufficiency due to R225X LMNA non-sense mutation was associated with accelerated nuclear senescence and apoptosis of iPSC- CMs under electrical stimulation, which can be significantly attenuated by therapeutic blockade of stress-related ERK1/2 pathway.
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Enteroviral 3C protease activates the human NLRP1 inflammasome in airway epithelia.
Kim S. Robinson,Daniel Eng Thiam Teo,Kai Sen Tan,Gee Ann Toh,Hsiao Hui Ong,Chrissie Lim,Kenneth Lay,Bijin Veonice Au,Tian Sheng Lew,Justin Jang Hann Chu,Justin Jang Hann Chu,Vincent T. K. Chow,De Yun Wang,Franklin L. Zhong,Bruno Reversade +14 more
TL;DR: In this article, the authors showed that human NACHT, LRR, and PYD domains-containing protein 1 (NLRP1) is activated by 3C proteases (3Cpros) of enteroviruses, such as human rhinovirus (HRV), which directly cleaves human NLRP1 at a single site between Glu130 and Gly131.
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FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential
TL;DR: It is suggested that HFSCs have restricted potential in vivo, which they conserve by coupling quiescence to adhesion-mediated niche maintenance, thereby achieving long-term tissue homeostasis.