J
Jenny Melnichenko
Researcher at Sheba Medical Center
Publications - 3
Citations - 622
Jenny Melnichenko is an academic researcher from Sheba Medical Center. The author has contributed to research in topics: Cancer & Peripheral blood mononuclear cell. The author has an hindex of 2, co-authored 2 publications receiving 136 citations.
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Journal ArticleDOI
Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients
Erez N. Baruch,Erez N. Baruch,Ilan Youngster,Guy Ben-Betzalel,Rona Ortenberg,Adi Lahat,Lior H. Katz,Katerina Adler,Daniela Dick-Necula,Stephen P. Raskin,Stephen P. Raskin,Naamah Bloch,Daniil Rotin,Liat Anafi,Camila Avivi,Jenny Melnichenko,Yael Steinberg-Silman,Ronac Mamtani,Hagit Harati,Nethanel Asher,Ronnie Shapira-Frommer,Tal Brosh-Nissimov,Yael Eshet,Yael Eshet,Shira Ben-Simon,Oren Ziv,Abdul Wadud Khan,Moran Amit,Nadim J. Ajami,Iris Barshack,Iris Barshack,Jacob Schachter,Jacob Schachter,Jennifer A. Wargo,Omry Koren,Gal Markel,Gal Markel,Ben Boursi,Ben Boursi,Ben Boursi +39 more
TL;DR: Treatment with FMT was associated with favorable changes in immune cell infiltrates and gene expression profiles in both the gut lamina propria and the tumor microenvironment, which have implications for modulating the gut microbiota in cancer treatment.
Proceedings ArticleDOI
Abstract CT042: Fecal microbiota transplantation (FMT) and re-induction of anti-PD-1 therapy in refractory metastatic melanoma patients - preliminary results from a phase I clinical trial (NCT03353402)
Erez N. Baruch,Ilan Youngster,Rona Ortenberg,Guy Ben-Betzalel,Lior H. Katz,Adi Lahat,Iris Barshack,Daniela Dick-Necula,Ronac Mamtani,Naamah Bloch,Bella Ungar,Daniel Rotin,Camila Avivi,Liat Anafi,Yael Steinberg-Silman,Nethanel Asher,Ronnie Shapira-Frommer,Tal Brosh-Nissimov,Yael Eshet,Stephen Raskin,Hagit Harati,Jenny Melnichenko,Jacob Schachter,Omry Koren,Gal Markel,Ben Boursi +25 more
TL;DR: FMT in metastatic melanoma patients seemed to be safe and may alter recipient gut microbiota to resemble that of a responder donor, which was translated to a clinical and radiological benefit in two recipients.
Journal ArticleDOI
Impact of cryopreservation on CAR T production and clinical response
Karin Brezinger-Dayan,Orit Itzhaki,Jenny Melnichenko,Adva Kubi,Li at Zeltzer,Elad Jacoby,Abraham Avigdor,R. Shapira Frommer,Michal J. Besser +8 more
TL;DR: Phenotype analysis including T cell subtypes, chemokine receptor and co-inhibitory/stimulatory molecules, revealed that fresh CAR T cells expressed significantly more TIM-3 and contained less effector T cells in comparison to their frozen counterparts, however cryopreservedCAR T cells still showed high anti-tumor potency and specificity.