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Ilan Youngster
Researcher at Tel Aviv University
Publications - 98
Citations - 5157
Ilan Youngster is an academic researcher from Tel Aviv University. The author has contributed to research in topics: Medicine & Vaccination. The author has an hindex of 25, co-authored 85 publications receiving 3509 citations. Previous affiliations of Ilan Youngster include Ben-Gurion University of the Negev & Western Galilee Hospital.
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Journal ArticleDOI
Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients
Erez N. Baruch,Erez N. Baruch,Ilan Youngster,Guy Ben-Betzalel,Rona Ortenberg,Adi Lahat,Lior H. Katz,Katerina Adler,Daniela Dick-Necula,Stephen P. Raskin,Stephen P. Raskin,Naamah Bloch,Daniil Rotin,Liat Anafi,Camila Avivi,Jenny Melnichenko,Yael Steinberg-Silman,Ronac Mamtani,Hagit Harati,Nethanel Asher,Ronnie Shapira-Frommer,Tal Brosh-Nissimov,Yael Eshet,Yael Eshet,Shira Ben-Simon,Oren Ziv,Abdul Wadud Khan,Moran Amit,Nadim J. Ajami,Iris Barshack,Iris Barshack,Jacob Schachter,Jacob Schachter,Jennifer A. Wargo,Omry Koren,Gal Markel,Gal Markel,Ben Boursi,Ben Boursi,Ben Boursi +39 more
TL;DR: Treatment with FMT was associated with favorable changes in immune cell infiltrates and gene expression profiles in both the gut lamina propria and the tumor microenvironment, which have implications for modulating the gut microbiota in cancer treatment.
Journal ArticleDOI
Oral, capsulized, frozen fecal microbiota transplantation for relapsing Clostridium difficile infection
Ilan Youngster,George Russell,Christina Pindar,Tomer Ziv-Baran,Jenny Sauk,Elizabeth L. Hohmann +5 more
TL;DR: This preliminary study among patients with relapsing C. difficile infection provides data on adverse events and rates of resolution of diarrhea following administration of FMT using frozen encapsulated inoculum from unrelated donors.
Journal ArticleDOI
Fecal Microbiota Transplant for Treatment of Clostridium difficile Infection in Immunocompromised Patients
Colleen R. Kelly,Chioma Ihunnah,Monika Fischer,Alexander Khoruts,Christina M. Surawicz,Anita Afzali,Olga C. Aroniadis,Amy Barto,Thomas J. Borody,Andrea Giovanelli,Shelley Gordon,Michael Gluck,Elizabeth L. Hohmann,Dina Kao,John Y. Kao,Daniel P. McQuillen,Mark Mellow,Kevin Rank,Krishna Rao,Arnab Ray,Margot Schwartz,Namita Singh,Neil Stollman,David L. Suskind,Stephen M. Vindigni,Ilan Youngster,Lawrence J. Brandt +26 more
TL;DR: This series demonstrates the effective use of FMT for CDI in IC patients with few SAEs or related AEs, and there were no related infectious complications in these high-risk patients.
Journal ArticleDOI
Fecal Microbiota Transplant for Relapsing Clostridium difficile Infection Using a Frozen Inoculum From Unrelated Donors: A Randomized, Open-Label, Controlled Pilot Study
Ilan Youngster,Jenny Sauk,Christina Pindar,Robin G. Wilson,Jess L. Kaplan,Mark Smith,Eric J. Alm,Dirk Gevers,George Russell,Elizabeth L. Hohmann +9 more
TL;DR: In the initial feasibility study, FMT using a frozen inoculum from unrelated donors is effective in treating relapsing CDI and NGT administration appears to be as effective as colonoscopy administration.
Journal ArticleDOI
Strain Tracking Reveals the Determinants of Bacterial Engraftment in the Human Gut Following Fecal Microbiota Transplantation.
Christopher Smillie,Christopher Smillie,Jenny Sauk,Dirk Gevers,Jonathan Friedman,Jaeyun Sung,Jaeyun Sung,Ilan Youngster,Ilan Youngster,Elizabeth L. Hohmann,Christopher Staley,Alexander Khoruts,Michael J. Sadowsky,Jessica R. Allegretti,Mark Smith,Ramnik J. Xavier,Eric J. Alm +16 more
TL;DR: A statistical model is built that predicts which bacterial species will engraft in a given host, and a method to infer strain genotypes and track them over time is developed, finding that engraftment can be predicted largely from the abundance and phylogeny of bacteria in the donor and the pre-FMT patient.