J
Jens Schmidt
Researcher at University of Göttingen
Publications - 77
Citations - 7576
Jens Schmidt is an academic researcher from University of Göttingen. The author has contributed to research in topics: Inclusion body myositis & Skeletal muscle. The author has an hindex of 25, co-authored 73 publications receiving 6706 citations. Previous affiliations of Jens Schmidt include National Institutes of Health & Foundation University, Islamabad.
Papers
More filters
Journal ArticleDOI
IL-1β-Induced Accumulation of Amyloid: Macroautophagy in Skeletal Muscle Depends on ERK
Karsten Schmidt,Magdalena Wienken,Christian W. Keller,Peter Balcarek,Christian Münz,Jens Schmidt +5 more
TL;DR: The data demonstrate that the ERK pathway contributes to formation of β-amyloid and regulation of autophagic activity in muscle cells exposed to proinflammatory cell stress and suggests that ERK serves as an important mediator between inflammatory mechanisms and protein deposition in skeletal muscle and is a crucial element of the pathology of IBM.
Journal ArticleDOI
Treatment with human immunoglobulin G improves the early disease course in a mouse model of Duchenne muscular dystrophy
Jana Zschüntzsch,Yaxin Zhang,Florian Klinker,Gregor Makosch,Lars Klinge,Dörthe Malzahn,Heinrich Brinkmeier,David Liebetanz,Jens Schmidt +8 more
TL;DR: It is demonstrated that, in the early disease course of mdx mice, human IgG improves the running performance and diminishes myopathic damage and inflammation in the muscle.
Journal ArticleDOI
TNF-α upregulates macroautophagic processing of APP/β-amyloid in a human rhabdomyosarcoma cell line
Christian W. Keller,Christian W. Keller,Matthias Schmitz,Christian Münz,Jan D. Lünemann,Jens Schmidt +5 more
TL;DR: It is shown that TNF-α-mediated upregulation of macroautophagy modulates APP and β-amyloid load and can be blocked by inhibition of macroAutophagy, which may be a crucial mediator between inflammation andβ-amymyloid-associated degeneration in skeletal muscle.
Journal ArticleDOI
Cell stress molecules in the skeletal muscle of GNE myopathy
Charlotte Fischer,Konstanze Kleinschnitz,Arne Wrede,Ingrid E. Muth,Niels Kruse,Ichizo Nishino,Jens Schmidt +6 more
TL;DR: The cell-stress molecules αB-crystallin and iNOS are overexpressed in GNE myopathy muscle and may identify early disease mechanisms.
Journal ArticleDOI
Molecular treatment effects of alemtuzumab in skeletal muscles of patients with IBM.
Karsten Schmidt,Konstanze Kleinschnitz,Goran Rakocevic,Marinos C. Dalakas,Marinos C. Dalakas,Jens Schmidt +5 more
TL;DR: Alemtuzumab showed a trend towards downregulation of the expression of some inflammatory molecules in skeletal muscle of IBM patients but has no effect on several crucial markers of cell stress and degeneration.