N
Niels Kruse
Researcher at University of Göttingen
Publications - 74
Citations - 4705
Niels Kruse is an academic researcher from University of Göttingen. The author has contributed to research in topics: Multiple sclerosis & Dementia with Lewy bodies. The author has an hindex of 30, co-authored 71 publications receiving 3989 citations. Previous affiliations of Niels Kruse include University of Würzburg.
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Journal ArticleDOI
Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis.
Harald H. Hofstetter,Saleh M. Ibrahim,Dirk Koczan,Niels Kruse,Andreas Weishaupt,Klaus V. Toyka,Ralf Gold +6 more
TL;DR: The role of IL-17 is crucially involved in the cytokine network as an effector cytokine in EAE and neutralization ofIL-17 with a monoclonal antibody also ameliorated the disease course.
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Characterizing mild cognitive impairment in incident Parkinson disease The ICICLE-PD Study
Alison J. Yarnall,David P. Breen,Gordon W Duncan,Tien K. Khoo,Shirley Coleman,Michael J. Firbank,Cristina Nombela,Sophie Winder-Rhodes,Jonathan R. Evans,James B. Rowe,Brit Mollenhauer,Niels Kruse,Gavin Hudson,Patrick F. Chinnery,John T. O'Brien,Trevor W. Robbins,Keith Wesnes,David J. Brooks,Roger A. Barker,David J. Burn +19 more
TL;DR: In a large cohort of newly diagnosed PD participants, PD-MCI is common and significantly correlates with lower cerebrospinal β-amyloid 1–42 and 1–40 levels and future longitudinal studies should enable us to determine those measures predictive of cognitive decline.
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A Practical Guide to Immunoassay Method Validation
Ulf Andreasson,Armand Perret-Liaudet,Linda J C van Waalwijk van Doorn,Kaj Blennow,Davide Chiasserini,Sebastiaan Engelborghs,Tormod Fladby,Sermin Genc,Niels Kruse,H. Bea Kuiperij,Luka Kulic,Piotr Lewczuk,Brit Mollenhauer,Barbara Mroczko,Lucilla Parnetti,Eugeen Vanmechelen,Marcel M. Verbeek,Bengt Winblad,Henrik Zetterberg,Henrik Zetterberg,Marleen J.A. Koel-Simmelink,Charlotte E. Teunissen +21 more
TL;DR: Standard operating procedures (SOPs) with step-by-step instructions for a number of different validation parameters is included in the present work together with a validation report template, which allow for a well-ordered presentation of the results.
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Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson’s disease and dementia with Lewy bodies
Anne Stuendl,Marcel Kunadt,Niels Kruse,Claudia Bartels,Wiebke Moebius,Karin M Danzer,Brit Mollenhauer,Anja Schneider +7 more
TL;DR: CSF exosomes of patients with Parkinson’s disease or dementia with Lewy bodies contain α- synuclein and induce α-synuclein aggregation in a reporter cell line, indicating that exosome support may support inter-neuronal transmission of α- Synuclein pathology.
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Recommendations to standardize preanalytical confounding factors in Alzheimer's and Parkinson's disease cerebrospinal fluid biomarkers: an update
Marta Del Campo,Brit Mollenhauer,Antonio Bertolotto,Sebastiaan Engelborghs,Harald Hampel,Anja Hviid Simonsen,Elisabeth Kapaki,Niels Kruse,Nathalie Le Bastard,Sylvain Lehmann,José Luis Molinuevo,Lucilla Parnetti,Armand Perret-Liaudet,Javier Sáez-Valero,Esen Saka,Andrea Urbani,Eugeen Vanmechelen,Marcel M. Verbeek,Pieter Jelle Visser,Charlotte E. Teunissen +19 more
TL;DR: Two previous consensus guidelines for preanalytical confounding factors for CSF biomarkers are merged to achieve one exhaustive guideline updated with new evidence for Aβ42, total tau and phosphorylated tau, and α-synuclein.