J
Jeremy F. L. Cobbold
Researcher at John Radcliffe Hospital
Publications - 66
Citations - 2208
Jeremy F. L. Cobbold is an academic researcher from John Radcliffe Hospital. The author has contributed to research in topics: Fatty liver & Medicine. The author has an hindex of 20, co-authored 53 publications receiving 1329 citations. Previous affiliations of Jeremy F. L. Cobbold include Imperial College London.
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Journal ArticleDOI
Accuracy of FibroScan Controlled Attenuation Parameter and Liver Stiffness Measurement in Assessing Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease
Peter J Eddowes,Magali Sasso,Michael Allison,Emmanouil Tsochatzis,Quentin M. Anstee,David Sheridan,Indra Neil Guha,Jeremy F. L. Cobbold,Jonathan J Deeks,Valérie Paradis,Pierre Bedossa,Philip N. Newsome,Philip N. Newsome +12 more
TL;DR: In a prospective analysis of patients with NAFLD, FibroScan vibration-controlled transient elastography controlled attenuation parameter (CAP) and liver stiffness measurement (LSMs) found to be effective in assessing liver steatosis and fibrosis, respectively, with AUROC values ranging from 0.70 to 0.89.
Journal ArticleDOI
FibroScan-AST (FAST) score for the non-invasive identification of patients with non-alcoholic steatohepatitis with significant activity and fibrosis: a prospective derivation and global validation study.
Philip N. Newsome,Philip N. Newsome,Magali Sasso,Jonathan J Deeks,Jonathan J Deeks,Angelo H. Paredes,Jérôme Boursier,Wah-Kheong Chan,Yusuf Yilmaz,Sébastien Czernichow,Ming-Hua Zheng,Ming-Hua Zheng,Vincent Wai-Sun Wong,Michael Allison,Emmanuel Tsochatzis,Quentin M. Anstee,David Sheridan,Peter J Eddowes,Indra Neil Guha,Jeremy F. L. Cobbold,Valérie Paradis,Pierre Bedossa,Véronique Miette,Céline Fournier-Poizat,Laurent Sandrin,Stephen A. Harrison +25 more
TL;DR: The FAST score provides an efficient way to non-invasively identify patients at risk of progressive NASH for clinical trials or treatments when they become available, and thereby reduce unnecessary liver biopsy in patients unlikely to have significant disease.
Journal ArticleDOI
Nonalcoholic Fatty Liver Disease in Adults: Current Concepts in Etiology, Outcomes, and Management.
Thomas Marjot,Thomas Marjot,Ahmad Moolla,Jeremy F. L. Cobbold,Leanne Hodson,Jeremy W. Tomlinson +5 more
TL;DR: The mechanisms that govern hepatic lipid accumulation and the predisposition to inflammation and fibrosis are still not fully understood, but reflect a complex interplay between metabolic target tissues and immune and inflammatory cells.
Journal ArticleDOI
Differences in gut microbial metabolism are responsible for reduced hippurate synthesis in Crohn's disease
Horace R T Williams,I. Jane Cox,David G. Walker,Jeremy F. L. Cobbold,Simon D. Taylor-Robinson,Sara E. Marshall,Timothy R. Orchard +6 more
TL;DR: A defect in the enzymatic conjugation of benzoate in CD has been excluded, strongly implicating altered gut microbial metabolism as the cause of decreased hippurate levels in CD.
Journal ArticleDOI
Serum metabolic profiling in inflammatory bowel disease.
Horace R T Williams,James D. Willsmore,I. Jane Cox,David G. Walker,Jeremy F. L. Cobbold,Simon D. Taylor-Robinson,Timothy R. Orchard +6 more
TL;DR: 1H NMR-based metabolic profiling has identified distinct differences in serum metabolic phenotype between CD and UC patients, as well as between IBD patients and controls.