FibroScan-AST (FAST) score for the non-invasive identification of patients with non-alcoholic steatohepatitis with significant activity and fibrosis: a prospective derivation and global validation study.
Philip N. Newsome,Philip N. Newsome,Magali Sasso,Jonathan J Deeks,Jonathan J Deeks,Angelo H. Paredes,Jérôme Boursier,Wah-Kheong Chan,Yusuf Yilmaz,Sébastien Czernichow,Ming-Hua Zheng,Ming-Hua Zheng,Vincent Wai-Sun Wong,Michael Allison,Emmanuel Tsochatzis,Quentin M. Anstee,David Sheridan,Peter J Eddowes,Indra Neil Guha,Jeremy F. L. Cobbold,Valérie Paradis,Pierre Bedossa,Véronique Miette,Céline Fournier-Poizat,Laurent Sandrin,Stephen A. Harrison +25 more
TLDR
The FAST score provides an efficient way to non-invasively identify patients at risk of progressive NASH for clinical trials or treatments when they become available, and thereby reduce unnecessary liver biopsy in patients unlikely to have significant disease.About:
This article is published in The Lancet Gastroenterology & Hepatology.The article was published on 2020-02-03 and is currently open access. It has received 339 citations till now. The article focuses on the topics: Prospective cohort study & Cohort.read more
Citations
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Non-alcoholic fatty liver disease
TL;DR: In this paper, a global prevalence of 25% and is a leading cause of cirrhosis and hepatocellular carcinoma, and the leading causes of death in people with NAFLD are cardiovascular disease and extrahepatic malignancy.
Journal ArticleDOI
Nonalcoholic Fatty Liver Disease 2020: The State of the Disease
Thomas G. Cotter,Mary E. Rinella +1 more
TL;DR: An update is provided on the epidemiology, clinical and prognostic features, and diagnostic approach to patients with NAFLD, with a view to targeting resources to those who need it most.
Journal ArticleDOI
EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis – 2021 update
Annalisa Berzigotti,Emmanouil Tsochatzis,Jérôme Boursier,Laurent Castera,Nora Cazzagon,Mireen Friedrich-Rust,Salvatore Petta,Maja Thiele +7 more
TL;DR: In this article, the authors provide the latest update to the EASL Clinical Practice Guidelines on the use of non-invasive tests for the evaluation of liver disease severity and prognosis.
Journal ArticleDOI
The Asian pacific association for the study of the liver clinical practice guidelines for the diagnosis and management of metabolic associated fatty liver disease
Mohammed Eslam,Shiv Kumar Sarin,Vincent Wai-Sun Wong,Jian-Gao Fan,Takumi Kawaguchi,Sang Hoon Ahn,Ming-Hua Zheng,Gamal Shiha,Yusuf Yilmaz,Rino Alvani Gani,Shahinul Alam,Yock Young Dan,Jia-Horng Kao,Saeed Hamid,Ian Homer Y. Cua,Wah-Kheong Chan,Diana A. Payawal,Soek Siam Tan,Tawesak Tanwandee,Leon A. Adams,Manoj Kumar,Masao Omata,Jacob George +22 more
TL;DR: The clinical practice guidelines of the Asian Pacific Association for the Study of the Liver on MAFLD are presented to improve patient care and awareness of the disease and assist stakeholders in the decision-making process by providing evidence-based data.
Journal ArticleDOI
Clinical Care Pathway for the Risk Stratification and Management of Patients With Nonalcoholic Fatty Liver Disease.
Fasiha Kanwal,Fasiha Kanwal,Jay H. Shubrook,Leon A. Adams,Kim Pfotenhauer,Vincent Wai-Sun Wong,Eugene E. Wright,Manal F. Abdelmalek,Stephen A. Harrison,Rohit Loomba,Christos S. Mantzoros,Elisabetta Bugianesi,Robert H. Eckel,Lee M. Kaplan,Hashem B. El-Serag,Hashem B. El-Serag,Kenneth Cusi,Kenneth Cusi +17 more
TL;DR: The American Gastroenterological Association ( AGA) developed a Clinical Care Pathway for nonalcoholic fatty liver disease (NAFLD) with clinically significant fibrosis (stage F2-F4) as mentioned in this paper.
References
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Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
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Regression Modeling Strategies
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Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection
Richard K. Sterling,Eduardo Lissen,Eduardo Lissen,Nathan Clumeck,Ricard Solà,Mendes Cassia Correa,Julio S. G. Montaner,Mark S. Sulkowski,Francesca J. Torriani,Doug T. Dieterich,David L. Thomas,Diethelm Messinger,Mark T. Nelson +12 more
TL;DR: In conclusion, noninvasive tests can accurately predict hepatic fibrosis and may reduce the need for liver biopsy in the majority of HIV/HCV‐coinfected patients.
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Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention
Zobair M. Younossi,Quentin M. Anstee,Milena Marietti,Timothy Hardy,Timothy Hardy,Linda Henry,Mohammed Eslam,Jacob George,Elisabetta Bugianesi +8 more
TL;DR: The large number of patients with NAFLD with potential for progressive liver disease creates challenges for screening, as the diagnosis of NASH necessitates invasive liver biopsy.
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Transparent Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis (TRIPOD): explanation and elaboration.
Karel G.M. Moons,Douglas G. Altman,Johannes B. Reitsma,John P. A. Ioannidis,Petra Macaskill,Ewout W. Steyerberg,Andrew J. Vickers,David F. Ransohoff,Gary S. Collins +8 more
TL;DR: In virtually all medical domains, diagnostic and prognostic multivariable prediction models are being developed, validated, updated, and implemented with the aim to assist doctors and individuals in estimating probabilities and potentially influence their decision making.