J
Jeremy S. Webb
Researcher at University of Southampton
Publications - 120
Citations - 9024
Jeremy S. Webb is an academic researcher from University of Southampton. The author has contributed to research in topics: Biofilm & Pseudomonas aeruginosa. The author has an hindex of 38, co-authored 111 publications receiving 7840 citations. Previous affiliations of Jeremy S. Webb include University of New South Wales & National Institute for Health Research.
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Journal ArticleDOI
A characterization of DNA release in Pseudomonas aeruginosa cultures and biofilms
Marie Allesen-Holm,Kim Bundvig Barken,Liang Yang,Mikkel Klausen,Jeremy S. Webb,Staffan Kjelleberg,Søren Molin,Michael Givskov,Tim Tolker-Nielsen +8 more
TL;DR: Experiments with P. aeruginosa strains indicated that the extracellular DNA is generated via a mechanism which is dependent on acyl homoserine lactone and Pseudomonas quinolone signalling, as well as on flagella and type IV pili.
Journal ArticleDOI
Involvement of Nitric Oxide in Biofilm Dispersal of Pseudomonas aeruginosa
Nicolas Barraud,Daniel J. Hassett,Sung Hei Hwang,Scott A. Rice,Staffan Kjelleberg,Jeremy S. Webb,Jeremy S. Webb +6 more
TL;DR: It is demonstrated that exposure to SNP greatly enhanced the efficacy of antimicrobial compounds in the removal of established P. aeruginosa biofilms from a glass surface and combined exposure to both NO and antimicrobial agents may offer a novel strategy to control preestablished, persistent P. aerobicaerobic bacteria.
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Enhanced Biofilm Formation and Increased Resistance to Antimicrobial Agents and Bacterial Invasion Are Caused by Synergistic Interactions in Multispecies Biofilms
Mette Burmølle,Jeremy S. Webb,Dhana Rao,Lars Hestbjerg Hansen,Søren J. Sørensen,Staffan Kjelleberg +5 more
TL;DR: It is strongly indicated that synergistic effects promote biofilm biomass and resistance of the biofilm to antimicrobial agents and bacterial invasion in multispecies biofilms.
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Cell Death in Pseudomonas aeruginosa Biofilm Development
Jeremy S. Webb,Lyndal S. Thompson,Sally James,Timothy S. Charlton,Tim Tolker-Nielsen,Birgit Koch,Michael Givskov,Staffan Kjelleberg +7 more
TL;DR: It is proposed that prophage-mediated cell death is an important mechanism of differentiation inside microcolonies that facilitates dispersal of a subpopulation of surviving cells in biofilms of P. aeruginosa.
Journal ArticleDOI
Nitric oxide signaling in Pseudomonas aeruginosa biofilms mediates phosphodiesterase activity, decreased cyclic Di-GMP levels, and enhanced dispersal
N. Barraud,David Schleheck,Janosch Klebensberger,Jeremy S. Webb,Daniel J. Hassett,Scott A. Rice,Staffan Kjelleberg +6 more
TL;DR: A role for c-di-GMP signaling in triggering the biofilm dispersal event induced by NO is suggested, as dispersal requires PDE activity and addition of NO stimulates PDE and induces the concomitant decrease in intracellular c- DiGMP levels in P. aeruginosa.