J
Jeroen P. Roose
Researcher at University of California, San Francisco
Publications - 91
Citations - 8350
Jeroen P. Roose is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Guanine nucleotide exchange factor & T cell. The author has an hindex of 35, co-authored 84 publications receiving 7771 citations. Previous affiliations of Jeroen P. Roose include University of Amsterdam & Utrecht University.
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Journal ArticleDOI
XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos
Miranda Molenaar,Marc van de Wetering,Mariëtte A. Oosterwegel,Josi Peterson-Maduro,Susan Godsave,Vladimir Korinek,Jeroen P. Roose,Olivier Destrée,Hans Clevers +8 more
TL;DR: It is proposed that signaling by beta-catenin involves complex formation with XT cf-3, followed by nuclear translocation and activation of specific XTcf-3 target genes, which suppresses endogenous axis specification upon injection into the dorsal blastomeres of a 4-cell-stage embryo.
Journal ArticleDOI
Drosophila Tcf and Groucho interact to repress Wingless signalling activity
Robert Cavallo,Rachel T. Cox,Melissa M. Moline,Jeroen P. Roose,Gordon Polevoy,Hans Clevers,Mark Peifer,Amy Bejsovec +7 more
TL;DR: It is reported that in the absence of Armadillo, dTcf acts as a transcriptional repressor of Wingless-responsive genes, and it is shown that Groucho act as a corepressor in this process.
Journal ArticleDOI
The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors
Jeroen P. Roose,Miranda Molenaar,Josi Peterson,Jolanda Hurenkamp,Helen Brantjes,Petra Moerer,Marc van de Wetering,Olivier Destrée,Hans Clevers +8 more
TL;DR: It is shown that Tcf factors physically interact with members of the Groucho family of transcriptional repressors, and secondary-axis formation induced by a dominant-positive Armadillo–Tcf fusion protein was inhibited by Xgrg-4 and enhanced by XGrg-5.
Journal ArticleDOI
Synergy Between Tumor Suppressor APC and the β-Catenin-Tcf4 Target Tcf1
Jeroen P. Roose,Gerwin Huls,Moniek van Beest,Petra Moerer,Karin van der Horn,Roel Goldschmeding,Ton Logtenberg,Hans Clevers +7 more
TL;DR: Tcf1 may act as a feedback repressor of beta-catenin-Tcf4 target genes and thus may cooperate with APC to suppress malignant transformation of epithelial cells.
Journal ArticleDOI
Digital Signaling and Hysteresis Characterize Ras Activation in Lymphoid Cells
Jayajit Das,Mary Ho,Julie Zikherman,Christopher C. Govern,Ming Yang,Arthur Weiss,Arthur Weiss,Arup K. Chakraborty,Jeroen P. Roose +8 more
TL;DR: It is demonstrated that digital signaling in lymphocytes (cells are "on" or "off") is predicated upon feedback regulation of SOS, which can enable a capacity to sustain Ras activation as stimuli are withdrawn and exhibit "memory" of past encounters with antigen.