O
Olivier Destrée
Researcher at University of Amsterdam
Publications - 70
Citations - 6684
Olivier Destrée is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Xenopus & Wnt signaling pathway. The author has an hindex of 29, co-authored 70 publications receiving 6476 citations. Previous affiliations of Olivier Destrée include Utrecht University & Ghent University.
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Journal ArticleDOI
XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos
Miranda Molenaar,Marc van de Wetering,Mariëtte A. Oosterwegel,Josi Peterson-Maduro,Susan Godsave,Vladimir Korinek,Jeroen P. Roose,Olivier Destrée,Hans Clevers +8 more
TL;DR: It is proposed that signaling by beta-catenin involves complex formation with XT cf-3, followed by nuclear translocation and activation of specific XTcf-3 target genes, which suppresses endogenous axis specification upon injection into the dorsal blastomeres of a 4-cell-stage embryo.
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The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors
Jeroen P. Roose,Miranda Molenaar,Josi Peterson,Jolanda Hurenkamp,Helen Brantjes,Petra Moerer,Marc van de Wetering,Olivier Destrée,Hans Clevers +8 more
TL;DR: It is shown that Tcf factors physically interact with members of the Groucho family of transcriptional repressors, and secondary-axis formation induced by a dominant-positive Armadillo–Tcf fusion protein was inhibited by Xgrg-4 and enhanced by XGrg-5.
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Expression pattern of Wnt signaling components in the adult intestine.
TL;DR: A much broader role for Wnt signaling in gut development and homeostasis than was previously anticipated from available genetic studies is predicted and novel factors likely involved in promoting canonical and noncanonical Wnt signals in the intestine are identified.
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Wnt Signaling Controls the Phosphorylation Status of β-Catenin
TL;DR: A monoclonal antibody is generated that recognizes an epitope containing two of the four residues of β-catenin when both are not phosphorylated, providing formal proof for the regulated phosphorylation of the Ser/Thr residues ofβ- catenin by Wnt signaling.
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Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse
Vladimir Korinek,Nick Barker,Karl Willert,Miranda Molenaar,Jeroen P. Roose,Gerry T.M. Wagenaar,Marry M. Markman,Wout H. Lamers,Olivier Destrée,Hans Clevers +9 more
TL;DR: A direct link between Wnt stimulation and β-catenin/Tcf transcriptional activation is demonstrated and imply a role formTcf-3 and -4 in early Wnt-driven developmental decisions in the mouse embryo.