J
Jérôme Boué
Researcher at French Institute of Health and Medical Research
Publications - 15
Citations - 684
Jérôme Boué is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Endogenous opioid & Enkephalin. The author has an hindex of 13, co-authored 15 publications receiving 580 citations. Previous affiliations of Jérôme Boué include Paul Sabatier University & University of Toulouse.
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Journal ArticleDOI
Food-Grade Bacteria Expressing Elafin Protect Against Inflammation and Restore Colon Homeostasis
Jean-Paul Motta,Luis G. Bermúdez-Humarán,Céline Deraison,Céline Deraison,Céline Deraison,Laurence Martin,Laurence Martin,Laurence Martin,Corinne Rolland,Corinne Rolland,Corinne Rolland,Perrine Rousset,Perrine Rousset,Perrine Rousset,Jérôme Boué,Jérôme Boué,Jérôme Boué,Gilles Dietrich,Gilles Dietrich,Gilles Dietrich,Kevin Chapman,Pascale Kharrat,Jean-Pierre Vinel,Laurent Alric,Emmanuel Mas,Jean-Michel Sallenave,Jean-Michel Sallenave,Jean-Michel Sallenave,Philippe Langella,Nathalie Vergnolle +29 more
TL;DR: Oral treatment with Elafin-expressing food-grade bacteria protected the gut from inflammatory damage and restored intestinal homeostasis in mouse models of acute and chronic colitis, and suggested that oral delivery of LAB secreting ElafIn may be useful for treating IBD in humans.
Journal ArticleDOI
Endogenous Regulation of Visceral Pain via Production of Opioids by Colitogenic CD4+ T Cells in Mice
Jérôme Boué,Jérôme Boué,Jérôme Boué,Lilian Basso,Lilian Basso,Lilian Basso,Nicolas Cenac,Nicolas Cenac,Nicolas Cenac,Catherine Blanpied,Catherine Blanpied,Catherine Blanpied,Malvyne Rolli–Derkinderen,Malvyne Rolli–Derkinderen,Michel Neunlist,Michel Neunlist,Nathalie Vergnolle,Gilles Dietrich,Gilles Dietrich,Gilles Dietrich +19 more
TL;DR: In mice with colitis, the local release of opioids by colitogenic CD4(+) T cells led to significant reduction of inflammation-associated visceral hypersensitivity, thereby reducing abdominal pain.
Journal ArticleDOI
Endogenous Opioid-Mediated Analgesia Is Dependent on Adaptive T Cell Response in Mice
TL;DR: Results show that CD4+ T lymphocytes acquire antinociceptive effector properties when specifically primed by Ag and point out analgesia as a property linked to the effector phase of adaptive T cell response.
Journal ArticleDOI
Thrombin receptor: An endogenous inhibitor of inflammatory pain, activating opioid pathways.
Laurence Martin,Céline Augé,Céline Augé,Jérôme Boué,Jérôme Boué,Michelle Buresi,Kevin Chapman,Samuel Asfaha,Patricia Andrade-Gordon,Martin Steinhoff,Nicolas Cenac,Nicolas Cenac,Gilles Dietrich,Gilles Dietrich,Nathalie Vergnolle,Nathalie Vergnolle,Nathalie Vergnolle +16 more
TL;DR: A previously unknown endogenous mechanism of analgesia is highlighted, showing a central role for the thrombin receptor PAR1 in the regulation of inflammatory pain and as an activator of opioid pathways.
Journal ArticleDOI
Immune conditions associated with CD4+ T effector-induced opioid release and analgesia.
Jérôme Boué,Jérôme Boué,Jérôme Boué,Catherine Blanpied,Catherine Blanpied,Catherine Blanpied,Marilena Djata-Cabral,Marilena Djata-Cabral,Marilena Djata-Cabral,Lucette Pelletier,Lucette Pelletier,Lucette Pelletier,Nathalie Vergnolle,Nathalie Vergnolle,Nathalie Vergnolle,Gilles Dietrich,Gilles Dietrich,Gilles Dietrich +17 more
TL;DR: Investigation of mechanisms of opioid release by antigen‐experienced effector CD4+ T cells that leave draining lymph nodes and come back into the inflammatory site showed that analgesia induced by T cell‐derived opioids is elicited via activation of δ‐type opioid receptors in the periphery.