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Jesse H. Goldberg

Researcher at Cornell University

Publications -  69
Citations -  4234

Jesse H. Goldberg is an academic researcher from Cornell University. The author has contributed to research in topics: Basal ganglia & Songbird. The author has an hindex of 24, co-authored 57 publications receiving 3836 citations. Previous affiliations of Jesse H. Goldberg include McGovern Institute for Brain Research & Howard Hughes Medical Institute.

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Protein kinase A regulates calcium permeability of NMDA receptors

TL;DR: This work shows that the Ca2+ permeability of neuronal NMDARs is under the control of the cyclic AMP–protein kinase A (cAMP-PKA) signaling cascade and provides a new mechanism whereby PKA regulates the induction of LTP.
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A hypothesis for basal ganglia-dependent reinforcement learning in the songbird.

TL;DR: This work outlines a specific working hypothesis for how BG-forebrain circuits could utilize an internally computed reinforcement signal to direct song learning, and includes a number of general concepts borrowed from the mammalian BG literature, including a dopaminergic reward prediction error and dopamine-mediated plasticity at corticostriatal synapses.
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Calcium Microdomains in Aspiny Dendrites

TL;DR: It is demonstrated using two-photon calcium imaging that activation of single synapses on aspiny dendrites of neocortical fast spiking (FS) interneurons creates highly localized calcium microdomains, often restricted to less than 1 microm of dendritic space.
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Multiphoton stimulation of neurons.

TL;DR: The combination of multiphoton stimulation and optical probing could enable systematic analysis of circuits and produce sustained depolarization, insensitive to sodium channel blockers yet sensitive to antioxidants.