J
Jessica A. Engel
Researcher at QIMR Berghofer Medical Research Institute
Publications - 25
Citations - 951
Jessica A. Engel is an academic researcher from QIMR Berghofer Medical Research Institute. The author has contributed to research in topics: T cell & Plasmodium falciparum. The author has an hindex of 9, co-authored 18 publications receiving 535 citations. Previous affiliations of Jessica A. Engel include Griffith University.
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Journal ArticleDOI
A practical guide to single-cell RNA-sequencing for biomedical research and clinical applications.
TL;DR: A practical guide to help researchers design their first scRNA-seq studies, including introductory information on experimental hardware, protocol choice, quality control, data analysis and biological interpretation is presented.
Journal ArticleDOI
The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation
Susanna S. Ng,Susanna S. Ng,Susanna S. Ng,Fabian de Labastida Rivera,Juming Yan,Juming Yan,Dillon Corvino,Dillon Corvino,Dillon Corvino,Indrajit Das,Ping Zhang,Rachel D. Kuns,Shashi Bhushan Chauhan,Jiajie Hou,Xian-Yang Li,Teija C. M. Frame,Teija C. M. Frame,Benjamin A. McEnroe,Eilish Moore,Eilish Moore,Jinrui Na,Jinrui Na,Jessica A. Engel,Megan S. F. Soon,Megan S. F. Soon,Bhawana Singh,Andrew J. Kueh,Andrew J. Kueh,Marco J Herold,Marco J Herold,Marcela Montes de Oca,Siddharth Sankar Singh,Patrick T. Bunn,Patrick T. Bunn,Amy Roman Aguilera,Mika Casey,Matthias Braun,Nazanin Ghazanfari,Shivangi Wani,Shivangi Wani,Yulin Wang,Yulin Wang,Fiona H. Amante,Chelsea L. Edwards,Chelsea L. Edwards,Ashraful Haque,William C. Dougall,Om Prakash Singh,Alan G. Baxter,Michele W.L. Teng,Alex Loukas,Norelle L. Daly,Nicole Cloonan,Nicole Cloonan,Mariapia A. Degli-Esposti,Mariapia A. Degli-Esposti,Jude E. Uzonna,William R. Heath,Tobias Bald,Siok-Keen Tey,Kyohei Nakamura,Geoffrey R. Hill,Rajiv Kumar,Shyam Sundar,Mark J. Smyth,Christian R. Engwerda +65 more
TL;DR: It is shown that natural killer cell granule protein 7 (NKG7) is a regulator of lymphocyte granule exocytosis and downstream inflammation in a broad range of diseases and is essential for type I and cytotoxic responses.
Journal ArticleDOI
Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites
Jessica A. Engel,Amy J. Jones,Vicky M. Avery,Subathdrage D. M. Sumanadasa,Susanna S. Ng,David P. Fairlie,Tina S. Adams,Katherine T. Andrews +7 more
TL;DR: In this study the in vitro activity of four anti-cancer HDAC inhibitors was examined against parasites that cause malaria and trypanosomiasis, and data indicate thatHDAC inhibitors may differentially affect the acetylation profiles of histone H3 and H4.
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Development of a Novel CD4+ TCR Transgenic Line That Reveals a Dominant Role for CD8+ Dendritic Cells and CD40 Signaling in the Generation of Helper and CTL Responses to Blood-Stage Malaria
Daniel Fernandez-Ruiz,Lei Shong Lau,Nazanin Ghazanfari,Claerwen M. Jones,Wei Yi Ng,Gayle M. Davey,Dorothée L. Berthold,Lauren E. Holz,Yu Kato,Matthias H. Enders,Ganchimeg Bayarsaikhan,Ganchimeg Bayarsaikhan,Sanne H. Hendriks,Lianne I. M. Lansink,Jessica A. Engel,Megan S. F. Soon,Kylie R. James,Anton Cozijnsen,Vanessa Mollard,Alessandro D. Uboldi,Christopher J. Tonkin,Tania F. de Koning-Ward,Paul R. Gilson,Tsuneyasu Kaisho,Ashraful Haque,Brendan S. Crabb,Francis R. Carbone,Geoffrey I. McFadden,William R. Heath +28 more
TL;DR: Evidence is provided that CD4+ T cell help, acting via CD40L signaling, can promote immunity or pathology to blood-stage malaria largely through Ag presentation by CD8+ DC.
Journal ArticleDOI
Transcriptome dynamics of CD4+ T cells during malaria maps gradual transit from effector to memory.
Megan S. F. Soon,Hyun Jae Lee,Hyun Jae Lee,Jessica A. Engel,Jasmin Straube,Bryce S. Thomas,Clara P. S. Pernold,Lachlan S. Clarke,Pawat Laohamonthonkul,Rohit N. Haldar,Cameron G. Williams,Cameron G. Williams,Lianne I. M. Lansink,Lianne I. M. Lansink,Marcela de Lima Moreira,Michael Bramhall,Lambros T. Koufariotis,Scott Wood,Xi Chen,Xi Chen,Xi Chen,Kylie R. James,Kylie R. James,Tapio Lönnberg,Steven W. Lane,Gabrielle T. Belz,Gabrielle T. Belz,Gabrielle T. Belz,Christian R. Engwerda,David S. Khoury,Miles P. Davenport,Valentine Svensson,Sarah A. Teichmann,Sarah A. Teichmann,Ashraful Haque,Ashraful Haque +35 more
TL;DR: The effector-to-memory transition in CD4 + T cells is gradual during malaria and is modulated by antiparasitic drugs.