Jessica H. Chancey

TL;DR: It is shown that the majority of the newborn cells undergo death by apoptosis in the first 1 to 4 days of their life, during the transition from amplifying neuroprogenitors to neuroblasts, which suggests a new role for microglia in maintaining the homeostasis of the baseline neurogenic cascade.

TL;DR: GA depolarization acutely allows NMDAR activation required for initial synapse unsilencing, revealing that adult-generated neurons in a critical period for survival use GABA signaling to rapidly initiate functional glutamate-mediated transmission in response to experience.

TL;DR: It is shown that hilar mossy cells provide initial glutamatergic synapses as well as disynaptic GABAergic input to adult-generated dentate GCs.

TL;DR: These dynamic functions of GABA across granule cell maturation are reviewed, focusing on the potential role of specific interneuron circuits at progressive developmental stages and questions that remain unanswered about GABA signaling ingranule cell development and excitability are highlighted.

TL;DR: It is shown that reduced GABA release probability and subsequent reduced short-term depression may act to overcome deficits in inhibition normalizing input/output functions in the Scn1a haploinsufficient hippocampus, and more complex circuit activity is likely required to reveal altered function in the hippocampal microcircuit.