Jesús Jiménez-Barbero

TL;DR: In this paper, a panel of small-molecule TLR4 agonists (the FP20 series) whose structure is derived from previously developed TLR 4 ligands (FP18 series) was revealed.

TL;DR: These studies, based on the use of NOESY experiments in combination with molecular dynamics simulations, indicate that for this particular fragment, initially characterized by a type I β-turn motif, the glycosylation with β-O-Glc forces the peptide backbone into an extended conformation.

TL;DR: In this article, the authors studied the role of hydrogen bonding and cation binding in the recognition processes in which carbohydrates are involved, and found that their relative participations are related to the topology of the carbohydrate, to the particular orientation of the residues exposed to the interaction, and to the medium which surrounds the sugar.

TL;DR: In this paper , the presence of fluorine did not significantly modify the affinity for glycan binding, which was in slow exchange on the 19F NMR chemical shift timescale, and allowed binding events taking place at two different binding sites within the same lectin to be individualized.