J
Jennifer Collins
Researcher at University of Bristol
Publications - 13
Citations - 861
Jennifer Collins is an academic researcher from University of Bristol. The author has contributed to research in topics: Lipid droplet & Fatty acid synthesis. The author has an hindex of 6, co-authored 13 publications receiving 699 citations. Previous affiliations of Jennifer Collins include University of Oxford.
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Journal ArticleDOI
Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation
Karim Bensaad,Elena Favaro,Caroline A. Lewis,Barrie Peck,Simon Lord,Jennifer Collins,Katherine E. Pinnick,Simon Wigfield,Francesca M. Buffa,Ji-Liang Li,Qifeng Zhang,Michael J.O. Wakelam,Fredrik Karpe,Fredrik Karpe,Almut Schulze,Adrian L. Harris +15 more
TL;DR: In this paper, the authors identify genes upregulated by bevacizumab treatment, including Fatty Acid Binding Protein 3 (FABP3) and FABP7, both of which are involved in fatty acid uptake.
Journal ArticleDOI
Leukocyte Activation by Triglyceride-Rich Lipoproteins
A. Alipour,Antonie J.H.H.M. van Oostrom,Alisa Izraeljan,C. Verseyden,Jennifer Collins,Keith N. Frayn,Thijs W.M. Plokker,Jan Willem F. Elte,Manuel Castro Cabezas +8 more
TL;DR: Acute hypertriglyceridemia is a leukocyte activator most likely by direct interaction between TRLs and leukocytes and uptake of fatty acids and adherence of apoB-containing lipoproteins.
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De Novo Lipogenesis and Stearoyl-CoA Desaturase Are Coordinately Regulated in the Human Adipocyte and Protect against Palmitate-induced Cell Injury
TL;DR: DNL may serve as a key regulator, in tandem with elongation and desaturation, to maintain cell membrane fluidity and insulin sensitivity within the human adipocyte to protect cells from SAFA toxicity.
Journal ArticleDOI
De novo lipogenesis in the differentiating human adipocyte can provide all fatty acids necessary for maturation
Jennifer Collins,Matt J. Neville,Katherine E. Pinnick,Leanne Hodson,Bente Ruyter,Theo H. van Dijk,Dirk-Jan Reijngoud,Mark D. Fielding,Keith N. Frayn +8 more
TL;DR: DNL in human fat cells is tightly coupled with further modification of fatty acids to produce a range of saturated and unsaturated fatty acids consistent with normal maturation and the pathway for conversion of glucose to palmitate is complex.
Journal ArticleDOI
Transcriptomic analysis of human primary breast cancer identifies fatty acid oxidation as a target for metformin
Simon Lord,Simon Lord,Jennifer Collins,Wei-Chen Cheng,Syed Haider,Simon Wigfield,Edoardo Gaude,Barbara A. Fielding,Barbara A. Fielding,Katherine E. Pinnick,Ulrike Harjes,Ashvina Segaran,Pooja Jha,Gerald Hoefler,Michael Pollak,Alastair M. Thompson,Pankaj G. Roy,Ruth English,R F Adams,Christian Frezza,Francesca M. Buffa,Fredrik Karpe,Adrian L. Harris,Adrian L. Harris +23 more
TL;DR: In vitro assays showed that, in contrast to previous studies in models of normal cells, metformin reduces fatty acid oxidation with a subsequent accumulation of intracellular triglyceride, independent of AMPK activation.