Jia Li

TL;DR: Results indicate BAK1 is a component of BR signaling, and Expression of a dominant-negative mutant allele of B AK1 causes a severe dwarf phenotype, resembling the phenotype of null bri1 alleles.

TL;DR: Serk3/BAK1 appears to integrate diverse perception events into downstream PAMP responses, leading to immunity against a range of invading microbes.

TL;DR: A sequential transphosphorylation model in which BRI1 controls signaling specificity by direct BR binding followed by substrate phosphorylation is proposed, which suggests both conservation and distinct differences between the molecular mechanisms regulating phosphorylated-dependent kinase activation in plant and animal receptor kinases.

TL;DR: Findings are consistent with many aspects of the animal receptor kinase model in which ligand-dependent autophosphorylation of the activation loop generates a functional kinase, whereas phosphorylated of noncatalytic intracellular domains is required for recognition and/or phosphorylations of downstream substrates.

TL;DR: This study provides novel insights into the initiation and crosstalk of the two signaling cascades of BRs, and demonstrates that BAK1 and BKK1 have dual physiological roles: positively regulating a BR-dependent plant growth pathway, and negatively regulating aBR-independent cell-death pathway.