J
Jia Ray Yu
Researcher at New York University
Publications - 18
Citations - 815
Jia Ray Yu is an academic researcher from New York University. The author has contributed to research in topics: Chromatin & PRC2. The author has an hindex of 9, co-authored 16 publications receiving 522 citations. Previous affiliations of Jia Ray Yu include Howard Hughes Medical Institute & Stony Brook University.
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Journal ArticleDOI
PRC2 is high maintenance
Jia Ray Yu,Jia Ray Yu,Chul Hwan Lee,Chul Hwan Lee,Ozgur Oksuz,Ozgur Oksuz,James M. Stafford,James M. Stafford,Danny Reinberg,Danny Reinberg +9 more
TL;DR: In this review, Yu et al. discuss the recent advances in knowledge of the Polycomb-repressive complex 2 (PRC2) in mammalian systems and discuss important discoveries on Polycomb function derived from model organisms in the context of understanding mammalian PRC2 function.
Journal ArticleDOI
Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma
James M. Stafford,Chul Hwan Lee,Philipp Voigt,Nicolas Descostes,Ricardo Saldaña-Meyer,Jia Ray Yu,Gary LeRoy,Ozgur Oksuz,Jessica R. Chapman,Fernando Suarez,Aram S. Modrek,N. Sumru Bayin,Dimitris G. Placantonakis,Matthias A. Karajannis,Matija Snuderl,Beatrix Ueberheide,Danny Reinberg +16 more
TL;DR: Quantitative proteomics reveals the conditions required for H3K27M-mediated PRC2 inhibition and reconcile seemingly paradoxical effects of H3k27M on PRC 2 recruitment and activity and suggests a more global, downstream effect on the epigenome.
Journal ArticleDOI
Allosteric Activation Dictates PRC2 Activity Independent of Its Recruitment to Chromatin
Chul Hwan Lee,Chul Hwan Lee,Jia Ray Yu,Jia Ray Yu,Sunil Kumar,Ying Jin,Gary LeRoy,Gary LeRoy,Natarajan V. Bhanu,Syuzo Kaneko,Syuzo Kaneko,Benjamin A. Garcia,Andrew D. Hamilton,Danny Reinberg,Danny Reinberg +14 more
TL;DR: With genetic and chemical tools, it is demonstrated that targeting allosteric activation overrode the gain-of-function effect of EZH2Y646X oncogenic mutations and revealed critical implications for the regulation and biology of PRC2 and a vulnerability in tacklingPRC2-addicted cancers.
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Distinct Stimulatory Mechanisms Regulate the Catalytic Activity of Polycomb Repressive Complex 2
Chul Hwan Lee,Chul Hwan Lee,Marlene Holder,Daniel Grau,Ricardo Saldaña-Meyer,Ricardo Saldaña-Meyer,Jia Ray Yu,Jia Ray Yu,Rais Ahmad Ganai,Rais Ahmad Ganai,Jenny Zhang,Miao Wang,Gary LeRoy,Gary LeRoy,Marc-Werner Dobenecker,Danny Reinberg,Danny Reinberg,Karim-Jean Armache +17 more
TL;DR: It is demonstrated that EZH1 and EZZH2, the two mutually exclusive catalytic subunits of PRC2, are differentially activated by various mechanisms, and that aPRC2-associated protein, AEBP2, can stimulate the activity of both complexes through a mechanism independent of and additive to allosteric activation.
Journal ArticleDOI
Automethylation of PRC2 promotes H3K27 methylation and is impaired in H3K27M pediatric glioma
Chul Hwan Lee,Chul Hwan Lee,Jia Ray Yu,Jia Ray Yu,Jeffrey Granat,Jeffrey Granat,Ricardo Saldaña-Meyer,Ricardo Saldaña-Meyer,Joshua Andrade,Gary LeRoy,Gary LeRoy,Ying Jin,Peder J. Lund,James M. Stafford,James M. Stafford,James M. Stafford,Benjamin A. Garcia,Beatrix Ueberheide,Danny Reinberg,Danny Reinberg +19 more
TL;DR: This study demonstrates a PRC2 self-regulatory mechanism through its EZH1/2-mediated automethylation activity, which promotesPRC2 accessibility to the histone H3 tail and is required for attaining proper cellular levels of H3K27me3.