J
James M. Stafford
Researcher at University of Vermont
Publications - 33
Citations - 2087
James M. Stafford is an academic researcher from University of Vermont. The author has contributed to research in topics: Chromatin & PRC2. The author has an hindex of 18, co-authored 33 publications receiving 1526 citations. Previous affiliations of James M. Stafford include New York University & Howard Hughes Medical Institute.
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Journal ArticleDOI
Pediatric high-grade glioma: biologically and clinically in need of new thinking
Chris Jones,Matthias A. Karajannis,David T.W. Jones,Mark W. Kieran,Michelle Monje,Suzanne J. Baker,Oren J. Becher,Yoon Jae Cho,Nalin Gupta,Cynthia Hawkins,Darren Hargrave,Daphne A. Haas-Kogan,Nada Jabado,Xiao-Nan Li,Sabine Mueller,Theo Nicolaides,Roger J. Packer,Anders Persson,Joanna J. Phillips,Erin F. Simonds,James M. Stafford,Yujie Tang,Stefan M. Pfister,Stefan M. Pfister,William A. Weiss +24 more
TL;DR: The current understanding of pediatric high-grade glioma is reviewed and approaches for innovative clinical management are suggested.
Journal ArticleDOI
An AUTS2-Polycomb complex activates gene expression in the CNS
Zhonghua Gao,Pedro Lee,James M. Stafford,Melanie J. von Schimmelmann,Anne Schaefer,Danny Reinberg +5 more
TL;DR: Findings reveal a natural means of subverting PRC1 activity, linking key epigenetic modulators with neuronal functions and diseases.
Journal ArticleDOI
Large-scale topology and the default mode network in the mouse connectome
James M. Stafford,Benjamin R. Jarrett,Oscar Miranda-Dominguez,Brian D. Mills,Nicholas Cain,Stefan Mihalas,Garet P. Lahvis,K. Matthew Lattal,Suzanne H. Mitchell,Stephen V. David,John D. Fryer,Joel T. Nigg,Damien A. Fair +12 more
TL;DR: This study is the first, to this knowledge, to use whole-brain functional imaging to show large-scale functional architecture with structural correlates in the mouse, and confirms the presence of basic network properties and functional networks of high translational importance in structural and functional systems in themouse brain.
Journal ArticleDOI
PRC2 is high maintenance
Jia Ray Yu,Jia Ray Yu,Chul Hwan Lee,Chul Hwan Lee,Ozgur Oksuz,Ozgur Oksuz,James M. Stafford,James M. Stafford,Danny Reinberg,Danny Reinberg +9 more
TL;DR: In this review, Yu et al. discuss the recent advances in knowledge of the Polycomb-repressive complex 2 (PRC2) in mammalian systems and discuss important discoveries on Polycomb function derived from model organisms in the context of understanding mammalian PRC2 function.
Journal ArticleDOI
Increasing histone acetylation in the hippocampus-infralimbic network enhances fear extinction.
TL;DR: The studies show that the memory modulating ability of drugs that enhance acetylation is sensitive to a variety of behavioral and molecular conditions.