Jian-Ge Qiu

TL;DR: Analysis of interleukin 6 (IL-6) gene expression in human esophagus cancer patients showed that IL-6 mRNA levels are significantly higher in tumor tissues and negatively correlated with overall survival, suggesting that IL -6 is a potential therapeutic target for esophageal cancer.

TL;DR: Experiments in animals showed that miR-143 inhibited tumor growth and angiogenesis by regulating IL-6/HIF-1α and downstream signaling pathways in vivo, and these outcomes support the hypothesis that the mi R-143/IL-6 / HIF- 1α pathway functions to regulate Cr(VI)-induced carcinogenesis.

TL;DR: This method exhibits a large dynamic range of 8 orders of mag-nitude and a detection limit of 0.16 aM, and can differentiate a single-base mismatch in miR-486-5p, quantify miR -486- 5p in lung cancer cells at various stages, and even discriminate the expressions of serum circulating miRNAs in healthy persons from that in nonsmall-cell lung carcinoma patients.

TL;DR: In this paper, a simple mix-and-read assay for the sensitive detection of DNA glycosylase using multiple cyclic enzymatic repairing amplification was developed. But, the detection of hOGG1 is critical for clinical diagnosis.

TL;DR: This review summarizes the recent advance in the development of nanosensors based on the integration of nanomaterials with nucleic acid amplification approaches for sensitive detection of DNAs, RNAs, enzymes, proteins, and small biomolecules and gives a new insight into their future directions.