J
Jian Luo
Researcher at East China Normal University
Publications - 67
Citations - 3533
Jian Luo is an academic researcher from East China Normal University. The author has contributed to research in topics: Osteoclast & Metastasis. The author has an hindex of 31, co-authored 67 publications receiving 2952 citations. Previous affiliations of Jian Luo include Second Military Medical University & Hunan Normal University.
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Journal ArticleDOI
Stereoselective synthesis of some methyl-substituted steroid hormones and their in vitro cytotoxic activity against human gastric cancer cell line MGC-803.
TL;DR: The preliminary SAR analysis showed that the methyl substituents at C-7alpha and C-15beta positions lead to a dramatical increase in potency against human gastric cancer cell line MGC-803.
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Caffeic acid 3,4-dihydroxy-phenethyl ester induces cancer cell senescence by suppressing twist expression
Anliang Dong,Yuanzhang Fang,Li Zhang,Juan Xie,Xian Wu,Lipeng Zhang,Xiaoyuan Lian,Yihua Chen,Jian Luo,Mingyao Liu +9 more
TL;DR: CADPE significantly suppressed the expression of Twist1 and led to the up-regulation of rat sarcoma, p53, p21WAF1/CIP1, and p16INK4a proteins in a dose-dependent manner, resulting in the hypophosphorylation of retinoblastoma protein.
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Loss of Lgr4 inhibits differentiation, migration and apoptosis, and promotes proliferation in bone mesenchymal stem cells.
Peng Sun,Kunhang Jia,Chunbing Zheng,Xinlei Zhu,Jing Li,Liang He,Stefan Siwko,Feng Xue,Mingyao Liu,Mingyao Liu,Jian Luo +10 more
TL;DR: It is demonstrated that Lgr4 is essential for mesoderm‐derived tissue development and BMSC differentiation, demonstrating that LGR4 could be a promising drug target for related diseases and a critical protein for stem cell therapy.
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LGR4/GPR48 inactivation leads to aniridia-genitourinary anomalies-mental retardation syndrome defects.
TL;DR: Evidence is provided that Lgr4, which regulates eye, kidney, testis, ovary, and uterine organ development as well as mental development through genetic and epigenetic surveillance, is a novel candidate gene for the pathogenesis of AGR syndrome.
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Regulation of Embryonic Kidney Branching Morphogenesis and Glomerular Development by KISS1 Receptor (Gpr54) through NFAT2- and Sp1-mediated Bmp7 Expression
Tingfang Yi,Kunrong Tan,Sung Gook Cho,Ying Wang,Jian Luo,Wenzheng Zhang,Dali Li,Mingyao Liu,Mingyao Liu +8 more
TL;DR: It is reported that Gpr54 deletion leads to kidney branching morphogenesis and glomerular development retardation in embryonic kidneys in vivo and in explanted kidneys in vitro and that NFAT2 cooperates with Sp1 to promote Bmp7 transcription activation.