D
Dali Li
Researcher at East China Normal University
Publications - 140
Citations - 5900
Dali Li is an academic researcher from East China Normal University. The author has contributed to research in topics: Gene & Genome editing. The author has an hindex of 37, co-authored 122 publications receiving 4471 citations. Previous affiliations of Dali Li include Hunan Normal University & Texas A&M University System.
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Journal ArticleDOI
Heritable gene targeting in the mouse and rat using a CRISPR-Cas system
Dali Li,Zhongwei Qiu,Yanjiao Shao,Yuting Chen,Yuting Guan,Meizhen Liu,Yongmei Li,Na Gao,Liren Wang,Xiaoling Lu,Yongxiang Zhao,Mingyao Liu,Mingyao Liu +12 more
TL;DR: A CRISPR-Cas system is used to induce genomic DNA fragment deletion in mice by coinjecting two single-guide RNAs (sgRNAs) targeting the Uhrf2 locus with Cas9 mRNA by means of a single microinjection.
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LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption.
Jian Luo,Zhengfeng Yang,Yu Ma,Zhiying Yue,Hongyu Lin,Guojun Qu,Jinping Huang,Wentao Dai,Chenghai Li,Chunbing Zheng,Leqin Xu,Huaqing Chen,Jiqiu Wang,Dali Li,Stefan Siwko,Josef M. Penninger,Guang Ning,Jianru Xiao,Jianru Xiao,Mingyao Liu,Mingyao Liu +20 more
TL;DR: It is reported that leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4, also called GPR48) is another receptor for RANKL that negatively regulates osteoclast differentiation and bone resorption.
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CRISPR/Cas-mediated genome editing in the rat via direct injection of one-cell embryos
Yanjiao Shao,Yuting Guan,Liren Wang,Zhongwei Qiu,Meizhen Liu,Yuting Chen,Lijuan Wu,Yongmei Li,Xueyun Ma,Mingyao Liu,Mingyao Liu,Dali Li +11 more
TL;DR: This protocol provides guidelines for the selection of genomic targets, synthesis of guide RNAs, design and construction of homologous recombination template vectors, embryo microinjection, and detection of mutations and insertions in founders or their progeny.
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Regulation of bone formation and remodeling by G-protein-coupled receptor 48
Jian Luo,Jian Luo,Jian Luo,Wei Zhou,Xin Zhou,Dali Li,Dali Li,Jinsheng Weng,Zhengfang Yi,Sung Gook Cho,Chenghai Li,Tingfang Yi,Xiushan Wu,Xiaoying Li,Benoit de Crombrugghe,Magnus Höök,Mingyao Liu,Mingyao Liu +17 more
TL;DR: Gpr48 regulates bone formation and remodeling through the cAMP-PKA-Atf4 signaling pathway and significantly downregulates the expression levels of Atf4 target genes/proteins, such as osteocalcin, bone sialoprotein and collagen.
Journal ArticleDOI
Orphan G protein-coupled receptors (GPCRs): biological functions and potential drug targets
TL;DR: This review focuses on the signaling transduction pathways of the adhesion GPCR family, the LGR sub family, and the PSGR subfamily, and their potential functions in immunology, development, and cancers.