J
Jianfeng Shen
Researcher at University of Texas MD Anderson Cancer Center
Publications - 28
Citations - 2001
Jianfeng Shen is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Cancer & Erythropoietin. The author has an hindex of 15, co-authored 27 publications receiving 1285 citations. Previous affiliations of Jianfeng Shen include Shanghai Jiao Tong University & Chinese Academy of Sciences.
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ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade
Jianfeng Shen,Zhenlin Ju,Wei Zhao,Lulu Wang,Yang Peng,Zhongqi Ge,Zachary D. Nagel,Jun Zou,Chen Wang,Prabodh Kapoor,Xiangyi Ma,Ding Ma,Jiyong Liang,Shumei Song,Jinsong Liu,Leona D. Samson,Jaffer A. Ajani,Guo Min Li,Han Liang,Xuetong Shen,Gordon B. Mills,Guang Peng +21 more
TL;DR: Results suggest ARID1A deficiency contributes to impaired MMR and mutator phenotype in cancer, and may cooperate with immune checkpoint blockade therapy, complementing MSI-based prognosis.
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ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors
Jianfeng Shen,Yang Peng,Leizhen Wei,Wei Zhang,Lin Yang,Li Lan,Prabodh Kapoor,Zhenlin Ju,Qianxing Mo,Ie Ming Shih,Ivan P. Uray,Xiangwei Wu,Powel H. Brown,Xuetong Shen,Gordon B. Mills,Guang Peng +15 more
TL;DR: A key function of ARID1A in regulating the DNA damage checkpoint is reported, suggesting that clinical utility of PARP inhibitors might be extended beyond patients with BRCA mutations to a larger group of patients with ARID 1A-mutant tumors, which may exhibit therapeutic vulnerability toPARP inhibitors.
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PARPi Triggers the STING-Dependent Immune Response and Enhances the Therapeutic Efficacy of Immune Checkpoint Blockade Independent of BRCAness
Jianfeng Shen,Wei Zhao,Zhenlin Ju,Lulu Wang,Yang Peng,Marilyne Labrie,Timothy A. Yap,Gordon B. Mills,Guang Peng +8 more
TL;DR: It is shown that PARPi-mediated modulation of the immune response contributes to their therapeutic effects independently of BRCA1/2 mutations, providing a mechanistic rationale for using PARPi as immunomodulatory agents to harness the therapeutic efficacy of immune checkpoint blockade.
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Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation
Yuhui Jiang,Yuhui Jiang,Xu Qian,Jianfeng Shen,Yugang Wang,Xinjian Li,Rui Liu,Rui Liu,Yan Xia,Qianming Chen,Guang Peng,Shiaw Yih Lin,Zhimin Lu,Zhimin Lu +13 more
TL;DR: Exposure to ionizing radiation induces DNA-PK-dependent phosphorylation of nuclear fumarase at Thr 236, which leads to an interaction betweenfumarase and the histone variant H2A, which increases the accumulation of the Ku70-containing DNA- PK at DSB regions for non-homologous end-joining DNA repair and cell survival.
Journal ArticleDOI
ERK- and Akt-dependent neuroprotection by erythropoietin (EPO) against glyoxal-AGEs via modulation of Bcl-xL, Bax, and BAD.
Jianfeng Shen,Yalan Wu,Jing-Ying Xu,Jing-Ying Xu,Jingfa Zhang,Jingfa Zhang,Stephen H. Sinclair,Myron Yanoff,Guoxu Xu,Weiye Li,Guo-Tong Xu,Guo-Tong Xu +11 more
TL;DR: It is demonstrated that exogenous EPO significantly attenuates the retinal neuronal cell death induced by glyoxal-AGEs by promoting antiapoptotic and suppressing apoptotic proteins.