J
Jianguo Wen
Researcher at Houston Methodist Hospital
Publications - 36
Citations - 914
Jianguo Wen is an academic researcher from Houston Methodist Hospital. The author has contributed to research in topics: Aptamer & Multiple myeloma. The author has an hindex of 18, co-authored 33 publications receiving 821 citations. Previous affiliations of Jianguo Wen include Wake Forest University & Fudan University.
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Journal ArticleDOI
Selective Gene Transfection of Individual Cells In Vitro with Plasmonic Nanobubbles
Ekaterina Y. Lukianova-Hleb,Adam Samaniego,Jianguo Wen,Leonid S. Metelitsa,Chung Che Chang,Dmitri O. Lapotko +5 more
TL;DR: Plasmonic nanobubbles (PNBs) provided targeted gene delivery at the single cell level in a single pulse procedure that can be used for safe and effective gene therapy.
Journal ArticleDOI
Screening genetically modified organisms using multiplex-PCR coupled with oligonucleotide microarray
Jia Xu,Haizhen Miao,Houfei Wu,Wensheng Huang,Rong Tang,Minyan Qiu,Jianguo Wen,Shuifang Zhu,Yao Li +8 more
TL;DR: A multiplex polymerase chain reaction (multiplex-PCR) coupled with a DNA microarray system simultaneously aiming at many targets in a consecutive reaction to detect a genetically modified organism (GMO).
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Enhanced antimyeloma cytotoxicity by the combination of arsenic trioxide and bortezomib is further potentiated by p38 MAPK inhibition.
Jianguo Wen,Yongdong Feng,Wan Ting Huang,Haiyun Chen,Bing Liao,Lawrence Rice,Hector Alejandro Preti,Rammurti T. Kamble,Youli Zu,Youli Zu,Douglas Ballon,Chung Che Chang,Chung Che Chang +12 more
TL;DR: The results suggest the opportunity for using p38 MAPK inhibition to enhance the efficacy of ATO+bortezomib in myeloma.
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Targeting the biophysical properties of the myeloma initiating cell niches: a pharmaceutical synergism analysis using multi-scale agent-based modeling.
Jing Su,Le Zhang,Le Zhang,Wen Zhang,Dong Song Choi,Jianguo Wen,Beini Jiang,Chung Che Chang,Xiaobo Zhou +8 more
TL;DR: Targeting the biophysical properties of stem cell niches is of high clinical potential since it may re-sensitize tumor initiating cells to chemotherapies and reduce risks of cancer relapse.
Journal ArticleDOI
Cancer stem cells: a review of potential clinical applications.
TL;DR: Major methods of CSC detection and isolation are described, with the emphasis on those techniques that are potentially relevant in clinical laboratory practice, and particular attention is given to CSC markers, such as cancer testis antigens, which could become promising targets in the development of immunotherapy in settings of minimal residual disease.