Showing papers by "Jianping Liu published in 2014"
TL;DR: Atheroprotective efficacy in model animal showed that HA-LT-rHDL had the best potent efficacy than other LT preparations, which was demonstrated by the fewest atherosclerotic lesions sizes, the most minimum mean intima-media thickness, the lowest macrophage infiltration and expression of matrix metalloproteinase-9 (MMP-9), respectively.
62 citations
TL;DR: In this article, the authors used failure mode and effect analysis (FMEA) methodology to assess the most important variables affecting enteric-coated pellets characteristics, and a Box-Behnken design was subsequently used for investigating the main, interactive, and quadratic effects of these variables on the response.
38 citations
TL;DR: With increment of AA modification amount, AA-LT-d-rHDL manifested lower reactivity with LCAT, thus significantly reducing the undesired drug leakage during the remodeling behaviors induced by LCAT.
Abstract: Our previous studies indicated that drug leaked from discoidal reconstituted high density lipoprotein (d-rHDL) during the remodeling behaviors induced by lecithin cholesterol acyl transferase (LCAT) abundant in circulation, thus decreasing the drug amount delivered into the target. In this study, arachidonic acid (AA)-modified d-rHDL loaded with lovastatin (LT) were engineered as AA-LT-d-rHDL to explore whether AA modification could reduce the drug leakage during the remodeling behaviors induced by LCAT and further deliver more drug into target cells to improve efficacy. After successful preparation of AA-LT-d-rHDL with different AA modification amount, a series of in vitro remodeling behaviors were investigated. Furthermore, inhibition on macrophage-derived foam cell formation was chosen to evaluate drug efficacy of AA-LT-d-rHDL. In vitro physicochemical characterizations studies showed that all LT-d-rHDL and AA-LT-d-rHDL preparations had nano-size, negative surface charge, high entrapment efficiency (EE) and comparable drug loading efficiency (DL). With increment of AA modification amount, AA-LT-d-rHDL manifested lower reactivity with LCAT, thus significantly reducing the undesired drug leakage during the remodeling behaviors induced by LCAT, eventually exerting stronger efficacy on inhibition of macrophage-derived foam cell formation. AA-LT-d-rHDL could decrease the drug leakage during the remodeling behaviors induced by LCAT and fulfill efficient drug delivery.
24 citations
TL;DR: The obtained physicochemical parameters provided insightful information useful to maximise DL into the liposomes, and explain a tendency of drug precipitation of pH-solubilized formulations following intravenous infusion.
16 citations
Patent•
28 May 2014
7 citations
TL;DR: Results demonstrated that MPOPs were potential formulations in treating angina pectoris induced by atherosclerosis.
6 citations
Patent•
20 Aug 2014
TL;DR: In this article, a method of total alkaloids of radix aconiti coreani and Guanfu A hydrochlorate was presented for preparing a slow sodium ion channel blocker and an antiarrhythmic medicine.
Abstract: The invention provides a preparation method of total alkaloids of radix aconiti coreani as well as an application of the total alkaloids of radix aconiti coreani in preparing a slow sodium ion channel blocker and an antiarrhythmic medicine Researches show that both the total alkaloids of radix aconiti coreani and Guanfu A hydrochlorate have an inhibiting effect on a slow sodium current of the ventricular muscle of a guinea pig The invention particularly relates to an application of the Guanfu base I in preparing enzyme inhibitors for drug metabolism The invention further provides an application of the Guanfu base A in preparing the slow sodium ion channel blocker
1 citations