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Antonio E. Muruato
Researcher at University of Texas Medical Branch
Publications - 47
Citations - 5536
Antonio E. Muruato is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Virus & Zika virus. The author has an hindex of 22, co-authored 38 publications receiving 3376 citations.
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Journal ArticleDOI
Spike mutation D614G alters SARS-CoV-2 fitness.
Jessica A. Plante,Yang Liu,Jianying Liu,Hongjie Xia,Bryan A. Johnson,Kumari G. Lokugamage,Xianwen Zhang,Antonio E. Muruato,Jing Zou,Camila R. Fontes-Garfias,Divya Mirchandani,Dionna Scharton,John P. Bilello,Zhiqiang Ku,Zhiqiang An,Birte Kalveram,Alexander N. Freiberg,Vineet D. Menachery,Xuping Xie,Kenneth S. Plante,Scott C. Weaver,Pei Yong Shi +21 more
TL;DR: Hamsters infected with SARS-CoV-2 expressing spike D614G (G614 virus) produced higher infectious titres in nasal washes and the trachea, but not in the lungs, supporting clinical evidence showing that the mutation enhances viral loads in the upper respiratory tract of COVID-19 patients and may increase transmission.
Journal ArticleDOI
An infectious cDNA clone of SARS-CoV-2
Xuping Xie,Antonio E. Muruato,Kumari G. Lokugamage,Krishna Narayanan,Xianwen Zhang,Jing Zou,Jianying Liu,Craig Schindewolf,Nathen E. Bopp,Patricia V. Aguilar,Kenneth S. Plante,Scott C. Weaver,Shinji Makino,James W. LeDuc,Vineet D. Menachery,Pei Yong Shi +15 more
TL;DR: The reverse genetic system and reporter virus provide key reagents to study SARS-CoV-2 and develop countermeasures and were successfully used to evaluate the antiviral activities of interferon (IFN).
Journal ArticleDOI
Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis.
Bryan A. Johnson,Xuping Xie,Adam L. Bailey,Birte Kalveram,Kumari G. Lokugamage,Antonio E. Muruato,Jing Zou,Xianwen Zhang,Terry L. Juelich,Jennifer K. Smith,Lihong Zhang,Nathen E. Bopp,Craig Schindewolf,Michelle N Vu,Abigail Vanderheiden,Emma S. Winkler,Daniele M. Swetnam,Jessica A. Plante,Patricia V. Aguilar,Kenneth S. Plante,Vsevolod L. Popov,Benhur Lee,Scott C. Weaver,Mehul S. Suthar,Andrew Routh,Ping Ren,Zhiqiang Ku,Zhiqiang An,Kari Debbink,Michael S. Diamond,Pei Yong Shi,Alexander N. Freiberg,Vineet D. Menachery +32 more
TL;DR: In this paper, a mutant SARS-CoV-2 that lacks the furin cleavage site (ΔPRRA) was generated, which had faster kinetics, improved fitness in Vero E6 cells and reduced spike protein processing.
Journal ArticleDOI
Characterization of a Novel Murine Model to Study Zika Virus
Shannan L. Rossi,Robert B. Tesh,Sasha R. Azar,Antonio E. Muruato,Kathryn A. Hanley,Albert J. Auguste,Rose M. Langsjoen,Slobodan Paessler,Nikos Vasilakis,Scott C. Weaver +9 more
TL;DR: Characterization of an Asian lineage ZIKV strain in a murine model, and one of the few studies reporting a model of Zika disease and demonstrating age-dependent morbidity and mortality, could provide a platform for testing the efficacy of antivirals and vaccines.
Journal ArticleDOI
A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation.
Antonio E. Muruato,Camila R. Fontes-Garfias,Ping Ren,Mariano A. Garcia-Blanco,Mariano A. Garcia-Blanco,Vineet D. Menachery,Xuping Xie,Pei Yong Shi +7 more
TL;DR: A fluorescence-based SARS-CoV-2 neutralization assay is reported on that detects Sars- CoV- 2 neutralizing antibodies in COVID-19 patient specimens and yields comparable results to plaque reduction neutralizing assay, the gold standard of serological testing.