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Bryan A. Johnson
Researcher at University of Texas Medical Branch
Publications - 23
Citations - 2840
Bryan A. Johnson is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Viral replication & Virus. The author has an hindex of 11, co-authored 17 publications receiving 1299 citations. Previous affiliations of Bryan A. Johnson include University of North Carolina at Chapel Hill.
Papers
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Journal ArticleDOI
Spike mutation D614G alters SARS-CoV-2 fitness.
Jessica A. Plante,Yang Liu,Jianying Liu,Hongjie Xia,Bryan A. Johnson,Kumari G. Lokugamage,Xianwen Zhang,Antonio E. Muruato,Jing Zou,Camila R. Fontes-Garfias,Divya Mirchandani,Dionna Scharton,John P. Bilello,Zhiqiang Ku,Zhiqiang An,Birte Kalveram,Alexander N. Freiberg,Vineet D. Menachery,Xuping Xie,Kenneth S. Plante,Scott C. Weaver,Pei Yong Shi +21 more
TL;DR: Hamsters infected with SARS-CoV-2 expressing spike D614G (G614 virus) produced higher infectious titres in nasal washes and the trachea, but not in the lungs, supporting clinical evidence showing that the mutation enhances viral loads in the upper respiratory tract of COVID-19 patients and may increase transmission.
Journal ArticleDOI
Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis.
Bryan A. Johnson,Xuping Xie,Adam L. Bailey,Birte Kalveram,Kumari G. Lokugamage,Antonio E. Muruato,Jing Zou,Xianwen Zhang,Terry L. Juelich,Jennifer K. Smith,Lihong Zhang,Nathen E. Bopp,Craig Schindewolf,Michelle N Vu,Abigail Vanderheiden,Emma S. Winkler,Daniele M. Swetnam,Jessica A. Plante,Patricia V. Aguilar,Kenneth S. Plante,Vsevolod L. Popov,Benhur Lee,Scott C. Weaver,Mehul S. Suthar,Andrew Routh,Ping Ren,Zhiqiang Ku,Zhiqiang An,Kari Debbink,Michael S. Diamond,Pei Yong Shi,Alexander N. Freiberg,Vineet D. Menachery +32 more
TL;DR: In this paper, a mutant SARS-CoV-2 that lacks the furin cleavage site (ΔPRRA) was generated, which had faster kinetics, improved fitness in Vero E6 cells and reduced spike protein processing.
Posted ContentDOI
Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant
Yang Liu,Jianying Liu,Bryan A. Johnson,Hongjie Xia,Zhiqiang Ku,Craig Schindewolf,Steven G. Widen,Zhiqiang An,Scott C. Weaver,Vineet D. Menachery,Xuping Xie,Pei Yong Shi +11 more
TL;DR: In this paper, the Delta spike mutation P681R plays a key role in the Alpha-to-Delta variant replacement and the Delta SARS-CoV-2 Delta variant has rapidly replaced the Alpha variant around the world.
Posted ContentDOI
Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility.
Jessica A. Plante,Yang Liu,Jianying Liu,Hongjie Xia,Bryan A. Johnson,Kumari G. Lokugamage,Xianwen Zhang,Antonio E. Muruato,Jing Zou,Camila R. Fontes-Garfias,Divya Mirchandani,Dionna Scharton,John P Bilello,Zhiqiang Ku,Zhiqiang An,Birte Kalveram,Alexander N. Freiberg,Vineet D. Menachery,Xuping Xie,Kenneth S. Plante,Scott C. Weaver,Pei Yong Shi +21 more
TL;DR: The D614G mutation significantly enhances SARS-CoV-2 replication on human lung epithelial cells and primary human airway tissues, through an improved infectivity of virions with the spike receptor-binding domain in an “up” conformation for binding to ACE2 receptor.
Journal ArticleDOI
Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant
Yang Liu,Jianying Liu,Bryan A. Johnson,Hongjie Xia,Zhiqiang Ku,Craig Schindewolf,Steven G. Widen,Zhiqiang An,Scott C. Weaver,Vineet D. Menachery,Xuping Xie,Pei Yong Shi +11 more
TL;DR: Liu et al. as discussed by the authors reported that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta spike mutation P681R plays a key role in the Alpha-to-Delta variant replacement during the COVID-19 pandemic.