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Jiawang Zhou
Researcher at Sun Yat-sen University
Publications - 11
Citations - 186
Jiawang Zhou is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 4 publications receiving 89 citations.
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Cancer-associated fibroblasts promote PD-L1 expression in mice cancer cells via secreting CXCL5
TL;DR: Results showed that CAFs promoted PD‐L1 expression in mice tumor cells, and the immunosuppressive action of CAFs on tumor cells is probably reflective of them being a potential therapeutic biomarker for melanoma and CRC.
Journal Article
Metformin attenuates PD-L1 expression through activating Hippo signaling pathway in colorectal cancer cells.
TL;DR: It is shown that metformin decreases PD-L1 and YAP1 expression in vitro and in vivo and suggests that met formin has the possibility to increase the efficacy of immunotherapy in human CRC.
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Nodal Facilitates Differentiation of Fibroblasts to Cancer-Associated Fibroblasts that Support Tumor Growth in Melanoma and Colorectal Cancer
Ziqian Li,Junjie Zhang,Jiawang Zhou,Linlin Lu,Hong-Sheng Wang,Ge Zhang,Guohui Wan,Shaohui Cai,Jun Du +8 more
TL;DR: It is demonstrated that intercellular crosstalk between cancer cells and fibroblasts is mediated by Nodal, which controls tumor growth, providing potential targets for the prevention and treatment of tumors.
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RNA m1A methylation regulates glycolysis of cancer cells through modulating ATP5D
Yingmin Wu,Zhuojia Chen,G. Xie,Haisheng Zhang,Zhaotong Wang,Jiawang Zhou,Fengli Chen,Jiexin Li,Likun Chen,Hongxin Niu,Hongsheng Wang +10 more
TL;DR: This study reveals a crosstalk of mRNA m1A modification and cell metabolism, which expands the understanding of such interplays that are essential for cancer therapeutic application.
Journal ArticleDOI
8-Acetonyldihydronitidine inhibits the proliferation of human colorectal cancer cells via activation of p53
TL;DR: 8-AHN displays an antitumor effect through cell cycle arrest and apoptosis in colorectal cells via activating p53, which suggests that 8- AHN, exerted a therapeutic potential against coloreCTal cancer cells, and may be regarded as an effective lead compound.