J
Jiexin Li
Researcher at Sun Yat-sen University
Publications - 28
Citations - 1894
Jiexin Li is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: Cancer & Cancer cell. The author has an hindex of 13, co-authored 20 publications receiving 1022 citations.
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Journal ArticleDOI
RNA m 6 A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail.
Xinyao Lin,Guo-Shi Chai,Yingmin Wu,Jiexin Li,Feng Chen,Jianzhao Liu,Guan-Zheng Luo,Guan-Zheng Luo,Jordi Tauler,Jun Du,Shuibin Lin,Chuan He,Hong-Sheng Wang +12 more
TL;DR: It is shown that m6A methylation of Snail mRNA regulates its translation with potential effects on epithelial mesenchymal transition, and the upregulation of METTL3 and YTHDF1 act as adverse prognosis factors for overall survival rate of liver cancer patients.
Journal ArticleDOI
m 6 A-induced lncRNA RP11 triggers the dissemination of colorectal cancer cells via upregulation of Zeb1
Yingmin Wu,Xiangling Yang,Zhuojia Chen,Lin Tian,Guanmin Jiang,Feng Chen,Jiexin Li,Panpan An,Linlin Lu,Nan Luo,Jun Du,Hong Shan,Huanliang Liu,Hong-Sheng Wang +13 more
TL;DR: m6A-induced lncRNA RP11 can trigger the dissemination of CRC cells via post-translational upregulation of Zeb1, and clinical analysis showed that m6A can regulate the expression of RP11.
Journal ArticleDOI
MiR-200b and miR-15b regulate chemotherapy-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting BMI1
Lijuan Sun,Y. Yao,Bodu Liu,Zhong-Ning Lin,Ling Lin,Meisongzhu Yang,W. M. Zhang,Wen Hui Chen,C. Pan,Qiang Liu,Erwei Song,Erwei Song,Jiexin Li +12 more
TL;DR: Stable chemotherapy-resistant tongue squamous cell carcinoma cell lines are established by exposing the parental CAL27 and SCC25 lines to escalating concentrations of cisplatin for 6 months and it is suggested that reduced expression of miR-200b and miB-15b underscores the mechanisms of chemotherapy-induced EMT in TSCC, and may serve as therapeutic targets to reverse chemotherapy resistance in tongue cancers.
Journal ArticleDOI
Transfer RNA demethylase ALKBH3 promotes cancer progression via induction of tRNA-derived small RNAs.
Zhuojia Chen,Zhuojia Chen,Meijie Qi,Bin Shen,Guan-Zheng Luo,Guan-Zheng Luo,Yingmin Wu,Jiexin Li,Zhike Lu,Zhong Zheng,Qing Dai,Hongsheng Wang,Hongsheng Wang +12 more
TL;DR: It is demonstrated that ALKBH3 is a 1-methyladenosine (m1A) and 3-methylcytidine (m3C) demethylase of t RNA, which opens a potential and novel paradigm of tRNA dem methylase, which regulates biological functions via generation of tDRs.
Journal ArticleDOI
N 6-methyladenosine regulates glycolysis of cancer cells through PDK4
Zihan Li,Zihan Li,Yanxi Peng,Yanxi Peng,Jiexin Li,Zhuojia Chen,Feng Chen,Jian Tu,Shuibin Lin,Hong-Sheng Wang +9 more
TL;DR: M6A methylation of pyruvate dehydrogenase kinase 4 (PDK4) positively regulates its mRNA stability and translation, and consequently affects glycolysis in cancer cells, as revealed by m6A-sequencing and functional studies.